Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells

Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells

Abstract Background Focal adhesion kinase (FAK) is a cytoplasmatic protein tyrosine kinase that associates with both integrins and growth factor receptors toward the adhesion, migration and invasion of cancer cells. The G-protein coupled estrogen receptor (GPER) has been involved in the stimulatory...

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Bibliographic Details
Main Authors: Damiano Cosimo Rigiracciolo, Maria Francesca Santolla, Rosamaria Lappano, Adele Vivacqua, Francesca Cirillo, Giulia Raffaella Galli, Marianna Talia, Lucia Muglia, Michele Pellegrino, Nijiro Nohata, Maria Teresa Di Martino, Marcello Maggiolini
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
TNBC
MDA-MB 231
SUM159
GPER
G-15
FAK
Online Access:http://link.springer.com/article/10.1186/s13046-019-1056-8

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