Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression
Leishmania braziliensis infection causes skin ulcers, typically found in localized cutaneous leishmaniasis (LCL). This tissue pathology associates with different modalities of cell necrosis, which are subverted by the parasite as a survival strategy. Herein we examined the participation of necroptos...
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doaj-ae631ad8b21a44a08842de6f0667c2252020-11-24T20:43:39ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-09-01910.3389/fmicb.2018.02283418424Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 ExpressionNivea F. Luz0Ricardo Khouri1Ricardo Khouri2Johan Van Weyenbergh3Johan Van Weyenbergh4Dalila L. Zanette5Dalila L. Zanette6Paloma P. Fiuza7Almerio Noronha8Aldina Barral9Aldina Barral10Viviane S. Boaventura11Viviane S. Boaventura12Deboraci B. Prates13Deboraci B. Prates14Francis Ka-Ming Chan15Bruno B. Andrade16Bruno B. Andrade17Bruno B. Andrade18Valeria M. Borges19Valeria M. Borges20Instituto Gonçalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilInstituto Gonçalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilFaculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, BrazilInstituto Gonçalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilDepartment of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, BelgiumInstituto Gonçalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilFaculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, BrazilInstituto Gonçalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilInstituto Gonçalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilInstituto Gonçalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilFaculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, BrazilInstituto Gonçalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilFaculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, BrazilInstituto Gonçalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilDepartamento de Biomorfologia, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, BrazilDepartment of Immunology, Duke University Medical Center, Durham, NC, United StatesInstituto Gonçalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilFaculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, BrazilMultinational Organization Network Sponsoring Translational and Epidemiological Research Initiative, Fundação José Silveira, Salvador, BrazilInstituto Gonçalo Moniz, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, BrazilFaculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, BrazilLeishmania braziliensis infection causes skin ulcers, typically found in localized cutaneous leishmaniasis (LCL). This tissue pathology associates with different modalities of cell necrosis, which are subverted by the parasite as a survival strategy. Herein we examined the participation of necroptosis, a specific form of programmed necrosis, in LCL lesions and found reduced RIPK3 and PGAM5 gene expression compared to normal skin. Assays using infected macrophages demonstrated that the parasite deactivates both RIPK3 and MLKL expression and that these molecules are important to control the intracellular L. braziliensis replication. Thus, LCL-related necroptosis may be targeted to control infection and disease immunopathology.https://www.frontiersin.org/article/10.3389/fmicb.2018.02283/fullRIPK3MLKLmacrophagenecroptosisLeishmania braziliensis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nivea F. Luz Ricardo Khouri Ricardo Khouri Johan Van Weyenbergh Johan Van Weyenbergh Dalila L. Zanette Dalila L. Zanette Paloma P. Fiuza Almerio Noronha Aldina Barral Aldina Barral Viviane S. Boaventura Viviane S. Boaventura Deboraci B. Prates Deboraci B. Prates Francis Ka-Ming Chan Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade Valeria M. Borges Valeria M. Borges |
spellingShingle |
Nivea F. Luz Ricardo Khouri Ricardo Khouri Johan Van Weyenbergh Johan Van Weyenbergh Dalila L. Zanette Dalila L. Zanette Paloma P. Fiuza Almerio Noronha Aldina Barral Aldina Barral Viviane S. Boaventura Viviane S. Boaventura Deboraci B. Prates Deboraci B. Prates Francis Ka-Ming Chan Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade Valeria M. Borges Valeria M. Borges Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression Frontiers in Microbiology RIPK3 MLKL macrophage necroptosis Leishmania braziliensis |
author_facet |
Nivea F. Luz Ricardo Khouri Ricardo Khouri Johan Van Weyenbergh Johan Van Weyenbergh Dalila L. Zanette Dalila L. Zanette Paloma P. Fiuza Almerio Noronha Aldina Barral Aldina Barral Viviane S. Boaventura Viviane S. Boaventura Deboraci B. Prates Deboraci B. Prates Francis Ka-Ming Chan Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade Valeria M. Borges Valeria M. Borges |
author_sort |
Nivea F. Luz |
title |
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression |
title_short |
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression |
title_full |
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression |
title_fullStr |
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression |
title_full_unstemmed |
Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression |
title_sort |
leishmania braziliensis subverts necroptosis by modulating ripk3 expression |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2018-09-01 |
description |
Leishmania braziliensis infection causes skin ulcers, typically found in localized cutaneous leishmaniasis (LCL). This tissue pathology associates with different modalities of cell necrosis, which are subverted by the parasite as a survival strategy. Herein we examined the participation of necroptosis, a specific form of programmed necrosis, in LCL lesions and found reduced RIPK3 and PGAM5 gene expression compared to normal skin. Assays using infected macrophages demonstrated that the parasite deactivates both RIPK3 and MLKL expression and that these molecules are important to control the intracellular L. braziliensis replication. Thus, LCL-related necroptosis may be targeted to control infection and disease immunopathology. |
topic |
RIPK3 MLKL macrophage necroptosis Leishmania braziliensis |
url |
https://www.frontiersin.org/article/10.3389/fmicb.2018.02283/full |
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