Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.
Pre-school age children account for 10%-20% of the 2 billion people worldwide who are infected with soil-transmitted helminths (STHs): Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), and Ancylostoma duodenale/Necator americanus (hookworms). Through a systematic review of the publis...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-03-01
|
Series: | PLoS Neglected Tropical Diseases |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18365031/?tool=EBI |
id |
doaj-ae6994fee4e14f698b7b652ba7e0b085 |
---|---|
record_format |
Article |
spelling |
doaj-ae6994fee4e14f698b7b652ba7e0b0852021-04-21T23:52:58ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352008-03-0123e12610.1371/journal.pntd.0000126Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.Marco AlbonicoHenrietta AllenLester ChitsuloDirk EngelsAlbis-Francesco GabrielliLorenzo SavioliPre-school age children account for 10%-20% of the 2 billion people worldwide who are infected with soil-transmitted helminths (STHs): Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), and Ancylostoma duodenale/Necator americanus (hookworms). Through a systematic review of the published literature and using information collated at World Health Organization headquarters, this paper summarizes the available evidence to support the recommendation that pre-school children should be included in regular deworming programmes. The first section describes the burden of STH disease in this age group, followed by a summary of how infection impacts iron status, growth, vitamin A status, and cognitive development and how STHs may exacerbate other high mortality infections. The second section explores the safety of the drugs themselves, given alone or co-administered, drug efficacy, and the importance of safe administration. The third section provides country-based evidence to demonstrate improved health outcomes after STH treatment. The final section provides country experiences in scaling up coverage of pre-school children by using other large scale public health interventions, including vitamin A programmes, immunization campaigns, and Child Health days. The paper concludes with a number of open research questions and a summary of some of the operational challenges that still need to be addressed.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18365031/?tool=EBI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marco Albonico Henrietta Allen Lester Chitsulo Dirk Engels Albis-Francesco Gabrielli Lorenzo Savioli |
spellingShingle |
Marco Albonico Henrietta Allen Lester Chitsulo Dirk Engels Albis-Francesco Gabrielli Lorenzo Savioli Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. PLoS Neglected Tropical Diseases |
author_facet |
Marco Albonico Henrietta Allen Lester Chitsulo Dirk Engels Albis-Francesco Gabrielli Lorenzo Savioli |
author_sort |
Marco Albonico |
title |
Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. |
title_short |
Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. |
title_full |
Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. |
title_fullStr |
Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. |
title_full_unstemmed |
Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. |
title_sort |
controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Neglected Tropical Diseases |
issn |
1935-2727 1935-2735 |
publishDate |
2008-03-01 |
description |
Pre-school age children account for 10%-20% of the 2 billion people worldwide who are infected with soil-transmitted helminths (STHs): Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), and Ancylostoma duodenale/Necator americanus (hookworms). Through a systematic review of the published literature and using information collated at World Health Organization headquarters, this paper summarizes the available evidence to support the recommendation that pre-school children should be included in regular deworming programmes. The first section describes the burden of STH disease in this age group, followed by a summary of how infection impacts iron status, growth, vitamin A status, and cognitive development and how STHs may exacerbate other high mortality infections. The second section explores the safety of the drugs themselves, given alone or co-administered, drug efficacy, and the importance of safe administration. The third section provides country-based evidence to demonstrate improved health outcomes after STH treatment. The final section provides country experiences in scaling up coverage of pre-school children by using other large scale public health interventions, including vitamin A programmes, immunization campaigns, and Child Health days. The paper concludes with a number of open research questions and a summary of some of the operational challenges that still need to be addressed. |
url |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18365031/?tool=EBI |
work_keys_str_mv |
AT marcoalbonico controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT henriettaallen controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT lesterchitsulo controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT dirkengels controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT albisfrancescogabrielli controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT lorenzosavioli controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy |
_version_ |
1714664040284815360 |