Transcriptional Studies on Trypanosoma cruzi – Host Cell Interactions: A Complex Puzzle of Variables
Chagas Disease, caused by the protozoan parasite Trypanosoma cruzi, affects nearly eight million people in the world. T. cruzi is a complex taxon represented by different strains with particular characteristics, and it has the ability to infect and interact with almost any nucleated cell. The T. cru...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-06-01
|
Series: | Frontiers in Cellular and Infection Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.692134/full |
id |
doaj-ae78c598527e4f56af260ded8dd64c89 |
---|---|
record_format |
Article |
spelling |
doaj-ae78c598527e4f56af260ded8dd64c892021-06-17T10:41:02ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-06-011110.3389/fcimb.2021.692134692134Transcriptional Studies on Trypanosoma cruzi – Host Cell Interactions: A Complex Puzzle of VariablesMaría Gabriela Libisch0Natalia Rego1Carlos Robello2Carlos Robello3Laboratorio de Interacciones Hospedero Patógeno-UBM, Institut Pasteur de Montevideo, Montevideo, UruguayUnidad de Bioinformática, Institut Pasteur de Montevideo, Montevideo, UruguayLaboratorio de Interacciones Hospedero Patógeno-UBM, Institut Pasteur de Montevideo, Montevideo, UruguayDepartamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, UruguayChagas Disease, caused by the protozoan parasite Trypanosoma cruzi, affects nearly eight million people in the world. T. cruzi is a complex taxon represented by different strains with particular characteristics, and it has the ability to infect and interact with almost any nucleated cell. The T. cruzi-host cell interactions will trigger molecular signaling cascades in the host cell that will depend on the particular cell type and T. cruzi strain, and also on many different experimental variables. In this review we collect data from multiple transcriptomic and functional studies performed in different infection models, in order to highlight key differences between works that in our opinion should be addressed when comparing and discussing results. In particular, we focus on changes in the respiratory chain and oxidative phosphorylation of host cells in response to infection, which depends on the experimental model of T. cruzi infection. Finally, we also discuss host cell responses which reiterate independently of the strain, cell type and experimental conditions.https://www.frontiersin.org/articles/10.3389/fcimb.2021.692134/fullTrypanosoma cruziChagas diseasetranscriptomicsrespiratory chainhost-pathogenChagas cardiomyopathy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
María Gabriela Libisch Natalia Rego Carlos Robello Carlos Robello |
spellingShingle |
María Gabriela Libisch Natalia Rego Carlos Robello Carlos Robello Transcriptional Studies on Trypanosoma cruzi – Host Cell Interactions: A Complex Puzzle of Variables Frontiers in Cellular and Infection Microbiology Trypanosoma cruzi Chagas disease transcriptomics respiratory chain host-pathogen Chagas cardiomyopathy |
author_facet |
María Gabriela Libisch Natalia Rego Carlos Robello Carlos Robello |
author_sort |
María Gabriela Libisch |
title |
Transcriptional Studies on Trypanosoma cruzi – Host Cell Interactions: A Complex Puzzle of Variables |
title_short |
Transcriptional Studies on Trypanosoma cruzi – Host Cell Interactions: A Complex Puzzle of Variables |
title_full |
Transcriptional Studies on Trypanosoma cruzi – Host Cell Interactions: A Complex Puzzle of Variables |
title_fullStr |
Transcriptional Studies on Trypanosoma cruzi – Host Cell Interactions: A Complex Puzzle of Variables |
title_full_unstemmed |
Transcriptional Studies on Trypanosoma cruzi – Host Cell Interactions: A Complex Puzzle of Variables |
title_sort |
transcriptional studies on trypanosoma cruzi – host cell interactions: a complex puzzle of variables |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2021-06-01 |
description |
Chagas Disease, caused by the protozoan parasite Trypanosoma cruzi, affects nearly eight million people in the world. T. cruzi is a complex taxon represented by different strains with particular characteristics, and it has the ability to infect and interact with almost any nucleated cell. The T. cruzi-host cell interactions will trigger molecular signaling cascades in the host cell that will depend on the particular cell type and T. cruzi strain, and also on many different experimental variables. In this review we collect data from multiple transcriptomic and functional studies performed in different infection models, in order to highlight key differences between works that in our opinion should be addressed when comparing and discussing results. In particular, we focus on changes in the respiratory chain and oxidative phosphorylation of host cells in response to infection, which depends on the experimental model of T. cruzi infection. Finally, we also discuss host cell responses which reiterate independently of the strain, cell type and experimental conditions. |
topic |
Trypanosoma cruzi Chagas disease transcriptomics respiratory chain host-pathogen Chagas cardiomyopathy |
url |
https://www.frontiersin.org/articles/10.3389/fcimb.2021.692134/full |
work_keys_str_mv |
AT mariagabrielalibisch transcriptionalstudiesontrypanosomacruzihostcellinteractionsacomplexpuzzleofvariables AT nataliarego transcriptionalstudiesontrypanosomacruzihostcellinteractionsacomplexpuzzleofvariables AT carlosrobello transcriptionalstudiesontrypanosomacruzihostcellinteractionsacomplexpuzzleofvariables AT carlosrobello transcriptionalstudiesontrypanosomacruzihostcellinteractionsacomplexpuzzleofvariables |
_version_ |
1721374092977766400 |