Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis
Abstract Background Triple Negative breast cancer (TNBC) includes a heterogeneous group of tumors with different clinico-pathological features, molecular alterations and treatment responsivity. Our aim was to evaluate the clinico-pathological heterogeneity and prognostic significance of TNBC histolo...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-06-01
|
Series: | BMC Cancer |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12885-020-06998-9 |
id |
doaj-ae814c38082d403bbe0df6d096104f57 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francesca Sanges Matteo Floris Paolo Cossu-Rocca Maria R. Muroni Giovanna Pira Silvana Anna Maria Urru Renata Barrocu Silvano Gallus Cristina Bosetti Maurizio D’Incalci Alessandra Manca Maria Gabriela Uras Ricardo Medda Elisabetta Sollai Alma Murgia Dolores Palmas Francesco Atzori Angelo Zinellu Francesca Cambosu Tiziana Moi Massimo Ghiani Vincenzo Marras Maria Cristina Santona Luisa Canu Enrichetta Valle Maria Giuseppina Sarobba Daniela Onnis Anna Asunis Sergio Cossu Sandra Orrù Maria Rosaria De Miglio |
spellingShingle |
Francesca Sanges Matteo Floris Paolo Cossu-Rocca Maria R. Muroni Giovanna Pira Silvana Anna Maria Urru Renata Barrocu Silvano Gallus Cristina Bosetti Maurizio D’Incalci Alessandra Manca Maria Gabriela Uras Ricardo Medda Elisabetta Sollai Alma Murgia Dolores Palmas Francesco Atzori Angelo Zinellu Francesca Cambosu Tiziana Moi Massimo Ghiani Vincenzo Marras Maria Cristina Santona Luisa Canu Enrichetta Valle Maria Giuseppina Sarobba Daniela Onnis Anna Asunis Sergio Cossu Sandra Orrù Maria Rosaria De Miglio Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis BMC Cancer Triple negative breast cancer Clinico-pathological features Prognosis Histologic special type Tumor size Metastatic lymph node |
author_facet |
Francesca Sanges Matteo Floris Paolo Cossu-Rocca Maria R. Muroni Giovanna Pira Silvana Anna Maria Urru Renata Barrocu Silvano Gallus Cristina Bosetti Maurizio D’Incalci Alessandra Manca Maria Gabriela Uras Ricardo Medda Elisabetta Sollai Alma Murgia Dolores Palmas Francesco Atzori Angelo Zinellu Francesca Cambosu Tiziana Moi Massimo Ghiani Vincenzo Marras Maria Cristina Santona Luisa Canu Enrichetta Valle Maria Giuseppina Sarobba Daniela Onnis Anna Asunis Sergio Cossu Sandra Orrù Maria Rosaria De Miglio |
author_sort |
Francesca Sanges |
title |
Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis |
title_short |
Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis |
title_full |
Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis |
title_fullStr |
Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis |
title_full_unstemmed |
Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis |
title_sort |
histologic subtyping affecting outcome of triple negative breast cancer: a large sardinian population-based analysis |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2020-06-01 |
description |
Abstract Background Triple Negative breast cancer (TNBC) includes a heterogeneous group of tumors with different clinico-pathological features, molecular alterations and treatment responsivity. Our aim was to evaluate the clinico-pathological heterogeneity and prognostic significance of TNBC histologic variants, comparing “special types” to high-grade invasive breast carcinomas of no special type (IBC-NST). Methods This study was performed on data obtained from TNBC Database, including pathological features and clinical records of 1009 TNBCs patients diagnosed between 1994 and 2015 in the four most important Oncology Units located in different hospitals in Sardinia, Italy. Kaplan-Meier analysis, log-rank test and multivariate Cox proportional-hazards regression were applied for overall survival (OS) and disease free survival (DFS) according to TNBC histologic types. Results TNBC “special types” showed significant differences for several clinico-pathological features when compared to IBC-NST. We observed that in apocrine carcinomas as tumor size increased, the number of metastatic lymph nodes manifestly increased. Adenoid cystic carcinoma showed the smallest tumor size relative to IBC-NST. At five-year follow-up, OS was 92.1, 100.0, and 94.5% for patients with apocrine, adenoid cystic and medullary carcinoma, respectively; patients with lobular and metaplastic carcinoma showed the worst OS, with 79.7 and 84.3%, respectively. At ten-years, patients with adenoid cystic (100.0%) and medullary (94.5%) carcinoma showed a favourable prognosis, whereas patients with lobular carcinoma showed the worst prognosis (73.8%). TNBC medullary type was an independent prognostic factor for DFS compared to IBC-NST. Conclusions Our study confirms that an accurate and reliable histopathologic definition of TNBC subtypes has a significant clinical utility and is effective in the therapeutic decision-making process, with the aim to develop innovative and personalized treatments. |
topic |
Triple negative breast cancer Clinico-pathological features Prognosis Histologic special type Tumor size Metastatic lymph node |
url |
http://link.springer.com/article/10.1186/s12885-020-06998-9 |
work_keys_str_mv |
AT francescasanges histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT matteofloris histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT paolocossurocca histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT mariarmuroni histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT giovannapira histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT silvanaannamariaurru histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT renatabarrocu histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT silvanogallus histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT cristinabosetti histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT mauriziodincalci histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT alessandramanca histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT mariagabrielauras histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT ricardomedda histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT elisabettasollai histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT almamurgia histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT dolorespalmas histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT francescoatzori histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT angelozinellu histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT francescacambosu histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT tizianamoi histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT massimoghiani histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT vincenzomarras histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT mariacristinasantona histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT luisacanu histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT enrichettavalle histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT mariagiuseppinasarobba histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT danielaonnis histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT annaasunis histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT sergiocossu histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT sandraorru histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis AT mariarosariademiglio histologicsubtypingaffectingoutcomeoftriplenegativebreastcanceralargesardinianpopulationbasedanalysis |
_version_ |
1724593385612771328 |
spelling |
doaj-ae814c38082d403bbe0df6d096104f572020-11-25T03:26:20ZengBMCBMC Cancer1471-24072020-06-0120111410.1186/s12885-020-06998-9Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysisFrancesca Sanges0Matteo Floris1Paolo Cossu-Rocca2Maria R. Muroni3Giovanna Pira4Silvana Anna Maria Urru5Renata Barrocu6Silvano Gallus7Cristina Bosetti8Maurizio D’Incalci9Alessandra Manca10Maria Gabriela Uras11Ricardo Medda12Elisabetta Sollai13Alma Murgia14Dolores Palmas15Francesco Atzori16Angelo Zinellu17Francesca Cambosu18Tiziana Moi19Massimo Ghiani20Vincenzo Marras21Maria Cristina Santona22Luisa Canu23Enrichetta Valle24Maria Giuseppina Sarobba25Daniela Onnis26Anna Asunis27Sergio Cossu28Sandra Orrù29Maria Rosaria De Miglio30Department of Biomedical Sciences, University of SassariDepartment of Biomedical Sciences, University of SassariDepartment of Medical, Surgical and Experimental Sciences, University of SassariDepartment of Medical, Surgical and Experimental Sciences, University of SassariDepartment of Biomedical Sciences, University of SassariBiomedicine Sector, Center for Advanced Studies, Research and Development in Sardinia Technology Park PolarisDepartment of Biomedical Sciences, University of SassariDepartment of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCSDepartment of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCSDepartment of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCSDepartment of Pathology, AOU SassariDepartment of Medical, Surgical and Experimental Sciences, University of SassariBiomedicine Sector, Center for Advanced Studies, Research and Development in Sardinia Technology Park PolarisDepartment of Pathology, “A. Businco” Oncologic Hospital, ASL CagliariDepartment of Pathology, “A. Businco” Oncologic Hospital, ASL CagliariDepartment of Medical Oncology, “A. Businco” Oncologic Hospital, ASL CagliariMedical Oncology Unit, AOUDepartment of Biomedical Sciences, University of SassariDepartment of Biomedical Sciences, University of SassariDepartment of Pathology, “A. Businco” Oncologic Hospital, ASL CagliariDepartment of Medical Oncology, “A. Businco” Oncologic Hospital, ASL CagliariDepartment of Pathology, AOU SassariDepartment of Pathology, ASSL NuoroDepartment of Pathology, ASSL NuoroDepartment of Medical Oncology, “A. Businco” Oncologic Hospital, ASL CagliariDepartment of Medical Oncology, ASSL NuoroDepartment of Pathology, Brotzu HospitalDepartment of Pathology, Brotzu HospitalDepartment of Pathology, ASSL NuoroDepartment of Pathology, “A. Businco” Oncologic Hospital, ASL CagliariDepartment of Medical, Surgical and Experimental Sciences, University of SassariAbstract Background Triple Negative breast cancer (TNBC) includes a heterogeneous group of tumors with different clinico-pathological features, molecular alterations and treatment responsivity. Our aim was to evaluate the clinico-pathological heterogeneity and prognostic significance of TNBC histologic variants, comparing “special types” to high-grade invasive breast carcinomas of no special type (IBC-NST). Methods This study was performed on data obtained from TNBC Database, including pathological features and clinical records of 1009 TNBCs patients diagnosed between 1994 and 2015 in the four most important Oncology Units located in different hospitals in Sardinia, Italy. Kaplan-Meier analysis, log-rank test and multivariate Cox proportional-hazards regression were applied for overall survival (OS) and disease free survival (DFS) according to TNBC histologic types. Results TNBC “special types” showed significant differences for several clinico-pathological features when compared to IBC-NST. We observed that in apocrine carcinomas as tumor size increased, the number of metastatic lymph nodes manifestly increased. Adenoid cystic carcinoma showed the smallest tumor size relative to IBC-NST. At five-year follow-up, OS was 92.1, 100.0, and 94.5% for patients with apocrine, adenoid cystic and medullary carcinoma, respectively; patients with lobular and metaplastic carcinoma showed the worst OS, with 79.7 and 84.3%, respectively. At ten-years, patients with adenoid cystic (100.0%) and medullary (94.5%) carcinoma showed a favourable prognosis, whereas patients with lobular carcinoma showed the worst prognosis (73.8%). TNBC medullary type was an independent prognostic factor for DFS compared to IBC-NST. Conclusions Our study confirms that an accurate and reliable histopathologic definition of TNBC subtypes has a significant clinical utility and is effective in the therapeutic decision-making process, with the aim to develop innovative and personalized treatments.http://link.springer.com/article/10.1186/s12885-020-06998-9Triple negative breast cancerClinico-pathological featuresPrognosisHistologic special typeTumor sizeMetastatic lymph node |