A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression
The stromal microenvironment plays a key role in the expansion of chronic lymphocytic leukemia. Here, the authors use the Eµ-TCL1 mouse model to show that leukemic B-cells induce the activation of retinoic acid synthesis in stromal cells of the lymphoid microenvironment, and that impacting on retino...
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2018-05-01
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doaj-ae8a25dfa5e64465b221fe7111cbb8b62021-05-11T09:27:18ZengNature Publishing GroupNature Communications2041-17232018-05-019111210.1038/s41467-018-04150-7A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progressionDiego Farinello0Monika Wozińska1Elisa Lenti2Luca Genovese3Silvia Bianchessi4Edoardo Migliori5Nicolò Sacchetti6Alessia di Lillo7Maria Teresa Sabrina Bertilaccio8Claudia de Lalla9Roberta Valsecchi10Sabrina Bascones Gleave11David Lligé12Cristina Scielzo13Laura Mauri14Maria Grazia Ciampa15Lydia Scarfò16Rosa Bernardi17Dejan Lazarevic18Blanca Gonzalez-Farre19Lucia Bongiovanni20Elias Campo21Andrea Cerutti22Maurilio Ponzoni23Linda Pattini24Federico Caligaris-Cappio25Paolo Ghia26Andrea Brendolan27Division of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteDivision of Immunology and Infection Disease, IRCCS, San Raffaele Scientific InstituteDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)Division of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteDepartment of Medical Biotechnology and Translational Medicine, University of MilanDepartment of Medical Biotechnology and Translational Medicine, University of MilanDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteCenter of Translational Genomics and Bioinformatics, IRCCS, San Raffaele Scientific InstituteInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic and University of BarcelonaPathology Unit, IRCCS San Raffaele Scientific InstituteInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic and University of BarcelonaProgram for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)Pathology Unit, IRCCS San Raffaele Scientific InstituteDepartment of Electronics, Information and Bioengineering, Politecnico di MilanoDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteDivision of Experimental Oncology, IRCCS, San Raffaele Scientific InstituteThe stromal microenvironment plays a key role in the expansion of chronic lymphocytic leukemia. Here, the authors use the Eµ-TCL1 mouse model to show that leukemic B-cells induce the activation of retinoic acid synthesis in stromal cells of the lymphoid microenvironment, and that impacting on retinoic acid signalling via diet or chemical inhibition prolonged survival by preventing leukemia dissemination and accumulation in lymphoid tissues.https://doi.org/10.1038/s41467-018-04150-7 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Diego Farinello Monika Wozińska Elisa Lenti Luca Genovese Silvia Bianchessi Edoardo Migliori Nicolò Sacchetti Alessia di Lillo Maria Teresa Sabrina Bertilaccio Claudia de Lalla Roberta Valsecchi Sabrina Bascones Gleave David Lligé Cristina Scielzo Laura Mauri Maria Grazia Ciampa Lydia Scarfò Rosa Bernardi Dejan Lazarevic Blanca Gonzalez-Farre Lucia Bongiovanni Elias Campo Andrea Cerutti Maurilio Ponzoni Linda Pattini Federico Caligaris-Cappio Paolo Ghia Andrea Brendolan |
spellingShingle |
Diego Farinello Monika Wozińska Elisa Lenti Luca Genovese Silvia Bianchessi Edoardo Migliori Nicolò Sacchetti Alessia di Lillo Maria Teresa Sabrina Bertilaccio Claudia de Lalla Roberta Valsecchi Sabrina Bascones Gleave David Lligé Cristina Scielzo Laura Mauri Maria Grazia Ciampa Lydia Scarfò Rosa Bernardi Dejan Lazarevic Blanca Gonzalez-Farre Lucia Bongiovanni Elias Campo Andrea Cerutti Maurilio Ponzoni Linda Pattini Federico Caligaris-Cappio Paolo Ghia Andrea Brendolan A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression Nature Communications |
author_facet |
Diego Farinello Monika Wozińska Elisa Lenti Luca Genovese Silvia Bianchessi Edoardo Migliori Nicolò Sacchetti Alessia di Lillo Maria Teresa Sabrina Bertilaccio Claudia de Lalla Roberta Valsecchi Sabrina Bascones Gleave David Lligé Cristina Scielzo Laura Mauri Maria Grazia Ciampa Lydia Scarfò Rosa Bernardi Dejan Lazarevic Blanca Gonzalez-Farre Lucia Bongiovanni Elias Campo Andrea Cerutti Maurilio Ponzoni Linda Pattini Federico Caligaris-Cappio Paolo Ghia Andrea Brendolan |
author_sort |
Diego Farinello |
title |
A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression |
title_short |
A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression |
title_full |
A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression |
title_fullStr |
A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression |
title_full_unstemmed |
A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression |
title_sort |
retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-05-01 |
description |
The stromal microenvironment plays a key role in the expansion of chronic lymphocytic leukemia. Here, the authors use the Eµ-TCL1 mouse model to show that leukemic B-cells induce the activation of retinoic acid synthesis in stromal cells of the lymphoid microenvironment, and that impacting on retinoic acid signalling via diet or chemical inhibition prolonged survival by preventing leukemia dissemination and accumulation in lymphoid tissues. |
url |
https://doi.org/10.1038/s41467-018-04150-7 |
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