Epigenetic regulation of miR-212 expression in lung cancer.

Epigenetic regulation of miR-212 expression in lung cancer.

Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by invest...

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Bibliographic Details
Main Authors: Mariarosaria Incoronato, Loredana Urso, Ana Portela, Mikko O Laukkanen, Ylermi Soini, Cristina Quintavalle, Simona Keller, Manel Esteller, Gerolama Condorelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3216999?pdf=render
Description
Summary:Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.
ISSN:1932-6203

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