Survey the Effect of Low Dose Aspirin on Serum Level of Uric Acid in Patients with Ischemic Heart Disease
Background & Objectives: Low dose aspirin has been widely used in the prevention and treatment of cardiovascular disease. The bimodel action of aspirin on serum uric acid showed that aspirin at a high dosage promoted uricusuria while intermediate doses were (1-2gr/day) caused uric acid retentio...
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Ardabil University of Medical Sciences
2012-11-01
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doaj-aeb7ad5d9ebf44dc8864ffba099b9ca22020-11-25T03:45:06ZfasArdabil University of Medical SciencesJournal of Ardabil University of Medical Sciences2228-72802228-72992012-11-011252432Survey the Effect of Low Dose Aspirin on Serum Level of Uric Acid in Patients with Ischemic Heart DiseaseBehzad Babapour0Shahram Habibzadeh1Alireza Mohammadzadeh2Nafiseh Mafi3Elham Atighi4Edalat Hoseinian5Bita Shahbazzadegan6 Background & Objectives: Low dose aspirin has been widely used in the prevention and treatment of cardiovascular disease. The bimodel action of aspirin on serum uric acid showed that aspirin at a high dosage promoted uricusuria while intermediate doses were (1-2gr/day) caused uric acid retention. The main goal of this study was to survey the effect of low dose aspirin on serum level of uric acid in patients with ischemic heart disease. Methods: The study design was cross-sectional and analytical type. In this study we selected 60 patients who used low dose aspirin among the patients of Imam Khomeini hospital's heart clinic (2008-9) and their information was registered in special questionnaires including serum level of uric acid and creatinine before and after prescription of aspirin. Data was then statistically analyzed using Paired t test and Willcoxon. Results: Of 60 patients 11 ( 18.3 % ) were under 50 years and 49 ( 81.7%) were above 50 years. The male to female ratio was 1.72 (38: 63.3% versus 22: 36.7%). 53.3 % of patients showed an increase in serum uric acid, but 46.7% did not. No significant differences in uric acid levels was found in patients under 50 years before and after administration of aspirin. Serum uric acid levels were increased after administration of 0.1unit of aspirin. Conclusion: Low -dose aspirin (80 mg/ day) caused a slight but significant increase in serum uric acid and creatinine levels in patients over 50 years of age.http://jarums.arums.ac.ir/browse.php?a_code=A-10-27-70&slc_lang=en&sid=1Aspirin; Uric Acid; Ischemic Heart Disease |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Behzad Babapour Shahram Habibzadeh Alireza Mohammadzadeh Nafiseh Mafi Elham Atighi Edalat Hoseinian Bita Shahbazzadegan |
spellingShingle |
Behzad Babapour Shahram Habibzadeh Alireza Mohammadzadeh Nafiseh Mafi Elham Atighi Edalat Hoseinian Bita Shahbazzadegan Survey the Effect of Low Dose Aspirin on Serum Level of Uric Acid in Patients with Ischemic Heart Disease Journal of Ardabil University of Medical Sciences Aspirin; Uric Acid; Ischemic Heart Disease |
author_facet |
Behzad Babapour Shahram Habibzadeh Alireza Mohammadzadeh Nafiseh Mafi Elham Atighi Edalat Hoseinian Bita Shahbazzadegan |
author_sort |
Behzad Babapour |
title |
Survey the Effect of Low Dose Aspirin on Serum Level of Uric Acid in Patients with Ischemic Heart Disease |
title_short |
Survey the Effect of Low Dose Aspirin on Serum Level of Uric Acid in Patients with Ischemic Heart Disease |
title_full |
Survey the Effect of Low Dose Aspirin on Serum Level of Uric Acid in Patients with Ischemic Heart Disease |
title_fullStr |
Survey the Effect of Low Dose Aspirin on Serum Level of Uric Acid in Patients with Ischemic Heart Disease |
title_full_unstemmed |
Survey the Effect of Low Dose Aspirin on Serum Level of Uric Acid in Patients with Ischemic Heart Disease |
title_sort |
survey the effect of low dose aspirin on serum level of uric acid in patients with ischemic heart disease |
publisher |
Ardabil University of Medical Sciences |
series |
Journal of Ardabil University of Medical Sciences |
issn |
2228-7280 2228-7299 |
publishDate |
2012-11-01 |
description |
Background & Objectives: Low dose aspirin has been widely used in the prevention and treatment of cardiovascular disease. The bimodel action of aspirin on serum uric acid showed that aspirin at a high dosage promoted uricusuria while intermediate doses were (1-2gr/day) caused uric acid retention. The main goal of this study was to survey the effect of low dose aspirin on serum level of uric acid in patients with ischemic heart disease. Methods: The study design was cross-sectional and analytical type. In this study we selected 60 patients who used low dose aspirin among the patients of Imam Khomeini hospital's heart clinic (2008-9) and their information was registered in special questionnaires including serum level of uric acid and creatinine before and after prescription of aspirin. Data was then statistically analyzed using Paired t test and Willcoxon. Results: Of 60 patients 11 ( 18.3 % ) were under 50 years and 49 ( 81.7%) were above 50 years. The male to female ratio was 1.72 (38: 63.3% versus 22: 36.7%). 53.3 % of patients showed an increase in serum uric acid, but 46.7% did not. No significant differences in uric acid levels was found in patients under 50 years before and after administration of aspirin. Serum uric acid levels were increased after administration of 0.1unit of aspirin. Conclusion: Low -dose aspirin (80 mg/ day) caused a slight but significant increase in serum uric acid and creatinine levels in patients over 50 years of age. |
topic |
Aspirin; Uric Acid; Ischemic Heart Disease |
url |
http://jarums.arums.ac.ir/browse.php?a_code=A-10-27-70&slc_lang=en&sid=1 |
work_keys_str_mv |
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