Common Kinetic Mechanism of Abasic Site Recognition by Structurally Different Apurinic/Apyrimidinic Endonucleases

Common Kinetic Mechanism of Abasic Site Recognition by Structurally Different Apurinic/Apyrimidinic Endonucleases

Apurinic/apyrimidinic (AP) endonucleases Nfo (<i>Escherichia coli</i>) and APE1 (human) represent two conserved structural families of enzymes that cleave AP-site–containing DNA in base excision repair. Nfo and APE1 have completely different structures of the DNA-binding site, catalytica...

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Bibliographic Details
Main Authors: Alexandra A. Kuznetsova, Svetlana I. Senchurova, Alexander A. Ishchenko, Murat Saparbaev, Olga S. Fedorova, Nikita A. Kuznetsov
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
DNA repair
apurinic/apyrimidinic endonuclease
damaged DNA
abasic site
conformational dynamics
stopped-flow enzyme kinetics
Online Access:https://www.mdpi.com/1422-0067/22/16/8874

Internet

https://www.mdpi.com/1422-0067/22/16/8874

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