The Biogenesis Process of VDAC – From Early Cytosolic Events to Its Final Membrane Integration
Voltage dependent anion-selective channel (VDAC) is the most abundant protein in the mitochondrial outer membrane. It is a membrane embedded β-barrel protein composed of 19 mostly anti-parallel β-strands that form a hydrophilic pore. Similar to the vast majority of mitochondrial proteins, VDAC is en...
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doaj-aec688dd71d34a26bb31739531b15ccf2021-08-12T07:54:15ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-08-011210.3389/fphys.2021.732742732742The Biogenesis Process of VDAC – From Early Cytosolic Events to Its Final Membrane IntegrationAnasuya MoitraDoron RapaportVoltage dependent anion-selective channel (VDAC) is the most abundant protein in the mitochondrial outer membrane. It is a membrane embedded β-barrel protein composed of 19 mostly anti-parallel β-strands that form a hydrophilic pore. Similar to the vast majority of mitochondrial proteins, VDAC is encoded by nuclear DNA, and synthesized on cytosolic ribosomes. The protein is then targeted to the mitochondria while being maintained in an import competent conformation by specific cytosolic factors. Recent studies, using yeast cells as a model system, have unearthed the long searched for mitochondrial targeting signal for VDAC and the role of cytosolic chaperones and mitochondrial import machineries in its proper biogenesis. In this review, we summarize our current knowledge regarding the early cytosolic stages of the biogenesis of VDAC molecules, the specific targeting of VDAC to the mitochondrial surface, and the subsequent integration of VDAC into the mitochondrial outer membrane by the TOM and TOB/SAM complexes.https://www.frontiersin.org/articles/10.3389/fphys.2021.732742/fullbeta-barrelschaperonesmitochondriaouter membraneTOM complexVDAC |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anasuya Moitra Doron Rapaport |
spellingShingle |
Anasuya Moitra Doron Rapaport The Biogenesis Process of VDAC – From Early Cytosolic Events to Its Final Membrane Integration Frontiers in Physiology beta-barrels chaperones mitochondria outer membrane TOM complex VDAC |
author_facet |
Anasuya Moitra Doron Rapaport |
author_sort |
Anasuya Moitra |
title |
The Biogenesis Process of VDAC – From Early Cytosolic Events to Its Final Membrane Integration |
title_short |
The Biogenesis Process of VDAC – From Early Cytosolic Events to Its Final Membrane Integration |
title_full |
The Biogenesis Process of VDAC – From Early Cytosolic Events to Its Final Membrane Integration |
title_fullStr |
The Biogenesis Process of VDAC – From Early Cytosolic Events to Its Final Membrane Integration |
title_full_unstemmed |
The Biogenesis Process of VDAC – From Early Cytosolic Events to Its Final Membrane Integration |
title_sort |
biogenesis process of vdac – from early cytosolic events to its final membrane integration |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2021-08-01 |
description |
Voltage dependent anion-selective channel (VDAC) is the most abundant protein in the mitochondrial outer membrane. It is a membrane embedded β-barrel protein composed of 19 mostly anti-parallel β-strands that form a hydrophilic pore. Similar to the vast majority of mitochondrial proteins, VDAC is encoded by nuclear DNA, and synthesized on cytosolic ribosomes. The protein is then targeted to the mitochondria while being maintained in an import competent conformation by specific cytosolic factors. Recent studies, using yeast cells as a model system, have unearthed the long searched for mitochondrial targeting signal for VDAC and the role of cytosolic chaperones and mitochondrial import machineries in its proper biogenesis. In this review, we summarize our current knowledge regarding the early cytosolic stages of the biogenesis of VDAC molecules, the specific targeting of VDAC to the mitochondrial surface, and the subsequent integration of VDAC into the mitochondrial outer membrane by the TOM and TOB/SAM complexes. |
topic |
beta-barrels chaperones mitochondria outer membrane TOM complex VDAC |
url |
https://www.frontiersin.org/articles/10.3389/fphys.2021.732742/full |
work_keys_str_mv |
AT anasuyamoitra thebiogenesisprocessofvdacfromearlycytosoliceventstoitsfinalmembraneintegration AT doronrapaport thebiogenesisprocessofvdacfromearlycytosoliceventstoitsfinalmembraneintegration AT anasuyamoitra biogenesisprocessofvdacfromearlycytosoliceventstoitsfinalmembraneintegration AT doronrapaport biogenesisprocessofvdacfromearlycytosoliceventstoitsfinalmembraneintegration |
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1721209705115680768 |