Advances in Research of Antitumor Mechanisms of Isothiocyanates

Isothiocyanates (ITCs) are naturally occurring small molecules that are generated by the enzymic hydrolysis of glucosinolate in cruciferous vegetables. Numerous studies showed that ITCs inhibit the growth of tumors by the mechanisms including inducing cell cycle arrest, promoting apoptosis and produ...

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Main Authors:	Huimin WANG, Ke XU
Format:	Article
Language:	zho
Published:	Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2017-03-01
Series:	Chinese Journal of Lung Cancer
Subjects:	Isothiocyanate Anti-tumor activity Apoptosis Cell cycle arrest Metastasis Autophagy
Online Access:	http://dx.doi.org/10.3779/j.issn.1009-3419.2017.03.11

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spelling	doaj-aee3edc1feda40b58b6b84c1f807204a2020-11-24T23:34:10ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872017-03-0120321321810.3779/j.issn.1009-3419.2017.03.11Advances in Research of Antitumor Mechanisms of IsothiocyanatesHuimin WANG0Ke XU1Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, ChinaTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, ChinaIsothiocyanates (ITCs) are naturally occurring small molecules that are generated by the enzymic hydrolysis of glucosinolate in cruciferous vegetables. Numerous studies showed that ITCs inhibit the growth of tumors by the mechanisms including inducing cell cycle arrest, promoting apoptosis and producing reactive oxygen species in vitro and in vivo. Recent studies showed that ITCs also inhibit metastasis of cancer cells, induce endoplasmic reticulum stress and autophagy. This review summarizes the antitumor mechanisms of ITCs.http://dx.doi.org/10.3779/j.issn.1009-3419.2017.03.11IsothiocyanateAnti-tumor activityApoptosisCell cycle arrestMetastasisAutophagy
collection	DOAJ
language	zho
format	Article
sources	DOAJ
author	Huimin WANG Ke XU
spellingShingle	Huimin WANG Ke XU Advances in Research of Antitumor Mechanisms of Isothiocyanates Chinese Journal of Lung Cancer Isothiocyanate Anti-tumor activity Apoptosis Cell cycle arrest Metastasis Autophagy
author_facet	Huimin WANG Ke XU
author_sort	Huimin WANG
title	Advances in Research of Antitumor Mechanisms of Isothiocyanates
title_short	Advances in Research of Antitumor Mechanisms of Isothiocyanates
title_full	Advances in Research of Antitumor Mechanisms of Isothiocyanates
title_fullStr	Advances in Research of Antitumor Mechanisms of Isothiocyanates
title_full_unstemmed	Advances in Research of Antitumor Mechanisms of Isothiocyanates
title_sort	advances in research of antitumor mechanisms of isothiocyanates
publisher	Chinese Anti-Cancer Association; Chinese Antituberculosis Association
series	Chinese Journal of Lung Cancer
issn	1009-3419 1999-6187
publishDate	2017-03-01
description	Isothiocyanates (ITCs) are naturally occurring small molecules that are generated by the enzymic hydrolysis of glucosinolate in cruciferous vegetables. Numerous studies showed that ITCs inhibit the growth of tumors by the mechanisms including inducing cell cycle arrest, promoting apoptosis and producing reactive oxygen species in vitro and in vivo. Recent studies showed that ITCs also inhibit metastasis of cancer cells, induce endoplasmic reticulum stress and autophagy. This review summarizes the antitumor mechanisms of ITCs.
topic	Isothiocyanate Anti-tumor activity Apoptosis Cell cycle arrest Metastasis Autophagy
url	http://dx.doi.org/10.3779/j.issn.1009-3419.2017.03.11
work_keys_str_mv	AT huiminwang advancesinresearchofantitumormechanismsofisothiocyanates AT kexu advancesinresearchofantitumormechanismsofisothiocyanates
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Advances in Research of Antitumor Mechanisms of Isothiocyanates

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