Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy Complications
Minimizing exposure of the fetus to medication and reducing adverse off-target effects in the mother are the primary challenges in developing novel drugs to treat pregnancy complications. Nanomedicine has introduced opportunities for the development of novel platforms enabling targeted delivery of d...
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doaj-aef5f06cd8e2407996eaab6907b3a2152020-11-24T21:29:14ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-07-012015364210.3390/ijms20153642ijms20153642Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy ComplicationsBaozhen Zhang0Ruijing Liang1Mingbin Zheng2Lintao Cai3Xiujun Fan4Center for Reproduction and Health Development, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaGuangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaGuangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaGuangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaCenter for Reproduction and Health Development, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaMinimizing exposure of the fetus to medication and reducing adverse off-target effects in the mother are the primary challenges in developing novel drugs to treat pregnancy complications. Nanomedicine has introduced opportunities for the development of novel platforms enabling targeted delivery of drugs in pregnancy. This review sets out to discuss the advances and potential of surface-functionalized nanoparticles in the targeted therapy of pregnancy complications. We first describe the human placental anatomy, which is fundamental for developing placenta-targeted therapy, and then we review current knowledge of nanoparticle transplacental transport mechanisms. Meanwhile, recent surface-functionalized nanoparticles for targeting the uterus and placenta are examined. Indeed, surface-functionalized nanoparticles could help prevent transplacental passage and promote placental-specific drug delivery, thereby enhancing efficacy and improving safety. We have achieved promising results in targeting the placenta via placental chondroitin sulfate A (plCSA), which is exclusively expressed in the placenta, using plCSA binding peptide (plCSA-BP)-decorated nanoparticles. Others have also focused on using placenta- and uterus-enriched molecules as targets to deliver therapeutics via surface-functionalized nanoparticles. Additionally, we propose that placenta-specific exosomes and surface-modified exosomes might be potential tools in the targeted therapy of pregnancy complications. Altogether, surface-functionalized nanoparticles have great potential value as clinical tools in the targeted therapy of pregnancy complications.https://www.mdpi.com/1422-0067/20/15/3642surface-functionalized nanoparticlespregnancy complicationsplacenta targetuterus targetplacenta-specific exosomesplCSA-BPtransplacental transport |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Baozhen Zhang Ruijing Liang Mingbin Zheng Lintao Cai Xiujun Fan |
spellingShingle |
Baozhen Zhang Ruijing Liang Mingbin Zheng Lintao Cai Xiujun Fan Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy Complications International Journal of Molecular Sciences surface-functionalized nanoparticles pregnancy complications placenta target uterus target placenta-specific exosomes plCSA-BP transplacental transport |
author_facet |
Baozhen Zhang Ruijing Liang Mingbin Zheng Lintao Cai Xiujun Fan |
author_sort |
Baozhen Zhang |
title |
Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy Complications |
title_short |
Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy Complications |
title_full |
Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy Complications |
title_fullStr |
Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy Complications |
title_full_unstemmed |
Surface-Functionalized Nanoparticles as Efficient Tools in Targeted Therapy of Pregnancy Complications |
title_sort |
surface-functionalized nanoparticles as efficient tools in targeted therapy of pregnancy complications |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-07-01 |
description |
Minimizing exposure of the fetus to medication and reducing adverse off-target effects in the mother are the primary challenges in developing novel drugs to treat pregnancy complications. Nanomedicine has introduced opportunities for the development of novel platforms enabling targeted delivery of drugs in pregnancy. This review sets out to discuss the advances and potential of surface-functionalized nanoparticles in the targeted therapy of pregnancy complications. We first describe the human placental anatomy, which is fundamental for developing placenta-targeted therapy, and then we review current knowledge of nanoparticle transplacental transport mechanisms. Meanwhile, recent surface-functionalized nanoparticles for targeting the uterus and placenta are examined. Indeed, surface-functionalized nanoparticles could help prevent transplacental passage and promote placental-specific drug delivery, thereby enhancing efficacy and improving safety. We have achieved promising results in targeting the placenta via placental chondroitin sulfate A (plCSA), which is exclusively expressed in the placenta, using plCSA binding peptide (plCSA-BP)-decorated nanoparticles. Others have also focused on using placenta- and uterus-enriched molecules as targets to deliver therapeutics via surface-functionalized nanoparticles. Additionally, we propose that placenta-specific exosomes and surface-modified exosomes might be potential tools in the targeted therapy of pregnancy complications. Altogether, surface-functionalized nanoparticles have great potential value as clinical tools in the targeted therapy of pregnancy complications. |
topic |
surface-functionalized nanoparticles pregnancy complications placenta target uterus target placenta-specific exosomes plCSA-BP transplacental transport |
url |
https://www.mdpi.com/1422-0067/20/15/3642 |
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