| Summary: | Ultraviolet B (UV-B, 280−320 nm) radiation causes complex molecular reactions in cells, including DNA damage, oxidative stress, and apoptosis. This study designed a mixture consisting of quercetin, luteolin and lycopene and used <i>Caenorhabditis elegans</i> as a model to study the resistance of these natural chemicals to UV-B. Specifically, we have confirmed that quercetin and its mixture can increase the resistance of <i>Caenorhabditis elegans</i> to UV-B through lifespan test, reactive oxygen species level assay, germ cell apoptosis test, embryonic lethal test and RT-qPCR experiments. The results show that quercetin and its mixture prolonged the lifespan of UV-B-irradiated <i>Caenorhabditis elegans</i> and reduced abnormal levels of reactive oxygen species, embryo death, and apoptosis induced by UV-B. The protective effect of quercetin and its mixture may be attributed to its down-regulation of <i>HUS-1</i>, <i>CEP-1</i>, <i>EGL-1</i> and <i>CED-13.</i> Therefore, the results of this research could help the development of UV-B radiation protection agents.
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