Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells

Caveolae are mechanosensors and mutations of their coat proteins are implicated in muscle disorders, but molecular mechanisms are unclear. Here, the authors show that caveolae can regulate IL6/STAT3 signaling in muscle cells under stress, and that dystrophy related Cav3 mutant myotubes have reduced...

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Main Authors:	Melissa Dewulf, Darius Vasco Köster, Bidisha Sinha, Christine Viaris de Lesegno, Valérie Chambon, Anne Bigot, Mona Bensalah, Elisa Negroni, Nicolas Tardif, Joanna Podkalicka, Ludger Johannes, Pierre Nassoy, Gillian Butler-Browne, Christophe Lamaze, Cedric M. Blouin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09405-5

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spelling	doaj-af0a410ef64d4e98b3b78ef974859a6d2021-05-11T11:53:26ZengNature Publishing GroupNature Communications2041-17232019-04-0110111310.1038/s41467-019-09405-5Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cellsMelissa Dewulf0Darius Vasco Köster1Bidisha Sinha2Christine Viaris de Lesegno3Valérie Chambon4Anne Bigot5Mona Bensalah6Elisa Negroni7Nicolas Tardif8Joanna Podkalicka9Ludger Johannes10Pierre Nassoy11Gillian Butler-Browne12Christophe Lamaze13Cedric M. Blouin14Membrane Dynamics and Mechanics of Intracellular Signaling Laboratory, Institut Curie – Centre de Recherche, PSL Research University, CNRS UMR3666, INSERM U1143Centre for Mechanochemical Cell Biology and Division of Biomedical Sciences, Warwick Medical School, University of WarwickDepartment of Biological Sciences, Indian Institute of Science Education and Research (IISER) KolkataMembrane Dynamics and Mechanics of Intracellular Signaling Laboratory, Institut Curie – Centre de Recherche, PSL Research University, CNRS UMR3666, INSERM U1143Endocytic Trafficking and Intracellular Delivery Laboratory, Institut Curie – Centre de Recherche, PSL Research University, CNRS UMR3666, INSERM U1143Association Institut de Myologie, Centre de Recherche en Myologie, Sorbonne Université, INSERM, UMRS974Association Institut de Myologie, Centre de Recherche en Myologie, Sorbonne Université, INSERM, UMRS974Association Institut de Myologie, Centre de Recherche en Myologie, Sorbonne Université, INSERM, UMRS974Membrane Dynamics and Mechanics of Intracellular Signaling Laboratory, Institut Curie – Centre de Recherche, PSL Research University, CNRS UMR3666, INSERM U1143Membrane Dynamics and Mechanics of Intracellular Signaling Laboratory, Institut Curie – Centre de Recherche, PSL Research University, CNRS UMR3666, INSERM U1143Endocytic Trafficking and Intracellular Delivery Laboratory, Institut Curie – Centre de Recherche, PSL Research University, CNRS UMR3666, INSERM U1143LP2N, CNRS UMR 5298, IOA, Institut d’Optique Graduate School, Université de BordeauxAssociation Institut de Myologie, Centre de Recherche en Myologie, Sorbonne Université, INSERM, UMRS974Membrane Dynamics and Mechanics of Intracellular Signaling Laboratory, Institut Curie – Centre de Recherche, PSL Research University, CNRS UMR3666, INSERM U1143Membrane Dynamics and Mechanics of Intracellular Signaling Laboratory, Institut Curie – Centre de Recherche, PSL Research University, CNRS UMR3666, INSERM U1143Caveolae are mechanosensors and mutations of their coat proteins are implicated in muscle disorders, but molecular mechanisms are unclear. Here, the authors show that caveolae can regulate IL6/STAT3 signaling in muscle cells under stress, and that dystrophy related Cav3 mutant myotubes have reduced caveolae and upregulated IL6 signaling.https://doi.org/10.1038/s41467-019-09405-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Melissa Dewulf Darius Vasco Köster Bidisha Sinha Christine Viaris de Lesegno Valérie Chambon Anne Bigot Mona Bensalah Elisa Negroni Nicolas Tardif Joanna Podkalicka Ludger Johannes Pierre Nassoy Gillian Butler-Browne Christophe Lamaze Cedric M. Blouin
spellingShingle	Melissa Dewulf Darius Vasco Köster Bidisha Sinha Christine Viaris de Lesegno Valérie Chambon Anne Bigot Mona Bensalah Elisa Negroni Nicolas Tardif Joanna Podkalicka Ludger Johannes Pierre Nassoy Gillian Butler-Browne Christophe Lamaze Cedric M. Blouin Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells Nature Communications
author_facet	Melissa Dewulf Darius Vasco Köster Bidisha Sinha Christine Viaris de Lesegno Valérie Chambon Anne Bigot Mona Bensalah Elisa Negroni Nicolas Tardif Joanna Podkalicka Ludger Johannes Pierre Nassoy Gillian Butler-Browne Christophe Lamaze Cedric M. Blouin
author_sort	Melissa Dewulf
title	Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
title_short	Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
title_full	Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
title_fullStr	Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
title_full_unstemmed	Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
title_sort	dystrophy-associated caveolin-3 mutations reveal that caveolae couple il6/stat3 signaling with mechanosensing in human muscle cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-04-01
description	Caveolae are mechanosensors and mutations of their coat proteins are implicated in muscle disorders, but molecular mechanisms are unclear. Here, the authors show that caveolae can regulate IL6/STAT3 signaling in muscle cells under stress, and that dystrophy related Cav3 mutant myotubes have reduced caveolae and upregulated IL6 signaling.
url	https://doi.org/10.1038/s41467-019-09405-5
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Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells

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