Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: The ELAPSE project
Background: Air pollution has been suggested as a risk factor for chronic obstructive pulmonary disease (COPD), but evidence is sparse and inconsistent. Objectives: We examined the association between long-term exposure to low-level air pollution and COPD incidence. Methods: Within the ‘Effects of L...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-01-01
|
Series: | Environment International |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412020322224 |
id |
doaj-af0e41060b84494b9ff57dd1608da4d5 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shuo Liu Jeanette T. Jørgensen Petter Ljungman Göran Pershagen Tom Bellander Karin Leander Patrik K.E. Magnusson Debora Rizzuto Ulla A. Hvidtfeldt Ole Raaschou-Nielsen Kathrin Wolf Barbara Hoffmann Bert Brunekreef Maciej Strak Jie Chen Amar Mehta Richard W. Atkinson Mariska Bauwelinck Raphaëlle Varraso Marie-Christine Boutron-Ruault Jørgen Brandt Giulia Cesaroni Francesco Forastiere Daniela Fecht John Gulliver Ole Hertel Kees de Hoogh Nicole A.H. Janssen Klea Katsouyanni Matthias Ketzel Jochem O. Klompmaker Gabriele Nagel Bente Oftedal Annette Peters Anne Tjønneland Sophia P. Rodopoulou Evangelia Samoli Terese Bekkevold Torben Sigsgaard Massimo Stafoggia Danielle Vienneau Gudrun Weinmayr Gerard Hoek Zorana J. Andersen |
spellingShingle |
Shuo Liu Jeanette T. Jørgensen Petter Ljungman Göran Pershagen Tom Bellander Karin Leander Patrik K.E. Magnusson Debora Rizzuto Ulla A. Hvidtfeldt Ole Raaschou-Nielsen Kathrin Wolf Barbara Hoffmann Bert Brunekreef Maciej Strak Jie Chen Amar Mehta Richard W. Atkinson Mariska Bauwelinck Raphaëlle Varraso Marie-Christine Boutron-Ruault Jørgen Brandt Giulia Cesaroni Francesco Forastiere Daniela Fecht John Gulliver Ole Hertel Kees de Hoogh Nicole A.H. Janssen Klea Katsouyanni Matthias Ketzel Jochem O. Klompmaker Gabriele Nagel Bente Oftedal Annette Peters Anne Tjønneland Sophia P. Rodopoulou Evangelia Samoli Terese Bekkevold Torben Sigsgaard Massimo Stafoggia Danielle Vienneau Gudrun Weinmayr Gerard Hoek Zorana J. Andersen Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: The ELAPSE project Environment International Air pollution COPD incidence Low-level exposure |
author_facet |
Shuo Liu Jeanette T. Jørgensen Petter Ljungman Göran Pershagen Tom Bellander Karin Leander Patrik K.E. Magnusson Debora Rizzuto Ulla A. Hvidtfeldt Ole Raaschou-Nielsen Kathrin Wolf Barbara Hoffmann Bert Brunekreef Maciej Strak Jie Chen Amar Mehta Richard W. Atkinson Mariska Bauwelinck Raphaëlle Varraso Marie-Christine Boutron-Ruault Jørgen Brandt Giulia Cesaroni Francesco Forastiere Daniela Fecht John Gulliver Ole Hertel Kees de Hoogh Nicole A.H. Janssen Klea Katsouyanni Matthias Ketzel Jochem O. Klompmaker Gabriele Nagel Bente Oftedal Annette Peters Anne Tjønneland Sophia P. Rodopoulou Evangelia Samoli Terese Bekkevold Torben Sigsgaard Massimo Stafoggia Danielle Vienneau Gudrun Weinmayr Gerard Hoek Zorana J. Andersen |
author_sort |
Shuo Liu |
title |
Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: The ELAPSE project |
title_short |
Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: The ELAPSE project |
title_full |
Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: The ELAPSE project |
title_fullStr |
Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: The ELAPSE project |
title_full_unstemmed |
Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: The ELAPSE project |
title_sort |
long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: the elapse project |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2021-01-01 |
description |
Background: Air pollution has been suggested as a risk factor for chronic obstructive pulmonary disease (COPD), but evidence is sparse and inconsistent. Objectives: We examined the association between long-term exposure to low-level air pollution and COPD incidence. Methods: Within the ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE) study, we pooled data from three cohorts, from Denmark and Sweden, with information on COPD hospital discharge diagnoses. Hybrid land use regression models were used to estimate annual mean concentrations of particulate matter with a diameter < 2.5 µm (PM2.5), nitrogen dioxide (NO2), and black carbon (BC) in 2010 at participants’ baseline residential addresses, which were analysed in relation to COPD incidence using Cox proportional hazards models. Results: Of 98,058 participants, 4,928 developed COPD during 16.6 years mean follow-up. The adjusted hazard ratios (HRs) and 95% confidence intervals for associations with COPD incidence were 1.17 (1.06, 1.29) per 5 µg/m3 for PM2.5, 1.11 (1.06, 1.16) per 10 µg/m3 for NO2, and 1.11 (1.06, 1.15) per 0.5 10−5m−1 for BC. Associations persisted in subset participants with PM2.5 or NO2 levels below current EU and US limit values and WHO guidelines, with no evidence for a threshold. HRs for NO2 and BC remained unchanged in two-pollutant models with PM2.5, whereas the HR for PM2.5 was attenuated to unity with NO2 or BC. Conclusions: Long-term exposure to low-level air pollution is associated with the development of COPD, even below current EU and US limit values and possibly WHO guidelines. Traffic-related pollutants NO2 and BC may be the most relevant. |
topic |
Air pollution COPD incidence Low-level exposure |
url |
http://www.sciencedirect.com/science/article/pii/S0160412020322224 |
work_keys_str_mv |
AT shuoliu longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT jeanettetjørgensen longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT petterljungman longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT goranpershagen longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT tombellander longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT karinleander longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT patrikkemagnusson longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT deborarizzuto longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT ullaahvidtfeldt longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT oleraaschounielsen longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT kathrinwolf longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT barbarahoffmann longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT bertbrunekreef longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT maciejstrak longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT jiechen longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT amarmehta longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT richardwatkinson longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT mariskabauwelinck longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT raphaellevarraso longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT mariechristineboutronruault longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT jørgenbrandt longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT giuliacesaroni longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT francescoforastiere longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT danielafecht longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT johngulliver longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT olehertel longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT keesdehoogh longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT nicoleahjanssen longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT kleakatsouyanni longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT matthiasketzel longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT jochemoklompmaker longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT gabrielenagel longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT benteoftedal longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT annettepeters longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT annetjønneland longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT sophiaprodopoulou longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT evangeliasamoli longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT teresebekkevold longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT torbensigsgaard longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT massimostafoggia longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT daniellevienneau longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT gudrunweinmayr longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT gerardhoek longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject AT zoranajandersen longtermexposuretolowlevelairpollutionandincidenceofchronicobstructivepulmonarydiseasetheelapseproject |
_version_ |
1724370038113173504 |
spelling |
doaj-af0e41060b84494b9ff57dd1608da4d52020-12-27T04:27:56ZengElsevierEnvironment International0160-41202021-01-01146106267Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: The ELAPSE projectShuo Liu0Jeanette T. Jørgensen1Petter Ljungman2Göran Pershagen3Tom Bellander4Karin Leander5Patrik K.E. Magnusson6Debora Rizzuto7Ulla A. Hvidtfeldt8Ole Raaschou-Nielsen9Kathrin Wolf10Barbara Hoffmann11Bert Brunekreef12Maciej Strak13Jie Chen14Amar Mehta15Richard W. Atkinson16Mariska Bauwelinck17Raphaëlle Varraso18Marie-Christine Boutron-Ruault19Jørgen Brandt20Giulia Cesaroni21Francesco Forastiere22Daniela Fecht23John Gulliver24Ole Hertel25Kees de Hoogh26Nicole A.H. Janssen27Klea Katsouyanni28Matthias Ketzel29Jochem O. Klompmaker30Gabriele Nagel31Bente Oftedal32Annette Peters33Anne Tjønneland34Sophia P. Rodopoulou35Evangelia Samoli36Terese Bekkevold37Torben Sigsgaard38Massimo Stafoggia39Danielle Vienneau40Gudrun Weinmayr41Gerard Hoek42Zorana J. Andersen43Department of Public Health, University of Copenhagen, Copenhagen, DenmarkDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Cardiology, Danderyd University Hospital, Stockholm, SwedenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Center for Occupational and Environmental Medicine, Region Stockholm, Stockholm, SwedenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Center for Occupational and Environmental Medicine, Region Stockholm, Stockholm, SwedenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenAging Research Center, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; The Stockholm Gerontology Research Center, Stockholm, SwedenDanish Cancer Society Research Center, Copenhagen, DenmarkDanish Cancer Society Research Center, Copenhagen, Denmark; Department of Environmental Science, Aarhus University, Roskilde, DenmarkInstitute of Epidemiology, Helmholtz Zentrum München, Neuherberg, GermanyInstitute of Occupational, Social and Environmental Medicine, Heinrich-Heine University Düsseldorf, Düsseldorf, GermanyInstitute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the NetherlandsInstitute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the Netherlands; National Institute for Public Health and the Environment (RIVM), Bilthoven, the NetherlandsInstitute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the NetherlandsDepartment of Public Health, University of Copenhagen, Copenhagen, DenmarkPopulation Health Research Institute, St George's, University of London, London, United KingdomInterface Demography, Department of Sociology, Vrije Universiteit Brussel, Brussels, BelgiumCESP, Faculté de Médecine, Université Paris-Saclay, UVSQ, Inserm UMR 1018, Villejuif, FranceCESP, Faculté de Médecine, Université Paris-Saclay, UVSQ, Inserm UMR 1018, Villejuif, France; Gustave Roussy, Villejuif, FranceDepartment of Environmental Science, Aarhus University, Roskilde, Denmark; iClimate, Aarhus University Interdisciplinary Center for Climate Change, Roskilde, DenmarkDepartment of Epidemiology, Lazio Regional Health Service, ASL Roma 1, Rome, ItalyDepartment of Epidemiology, Lazio Regional Health Service, ASL Roma 1, Rome, ItalyMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United KingdomUK Small Area Health Statistics Unit, Department of Epidemiology & Biostatistics, Imperial College London, London, United Kingdom; Centre for Environmental Health and Sustainability & School of Geography, Geology and the Environment, University of Leicester, Leicester, United KingdomDepartment of Environmental Science, Aarhus University, Roskilde, DenmarkSwiss Tropical and Public Health Institute, Basel, SwitzerlandNational Institute for Public Health and the Environment (RIVM), Bilthoven, the NetherlandsDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Environmental Science, Aarhus University, Roskilde, Denmark; Global Centre for Clean Air Research, University of Surrey, Guildford, United KingdomInstitute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the Netherlands; National Institute for Public Health and the Environment (RIVM), Bilthoven, the NetherlandsInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, GermanyDepartment of Environmental Health, Norwegian Institute of Public Health, Oslo, NorwayInstitute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany; Chair of Epidemiology, Ludwig Maximilians Universität München, Munich, GermanyDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark; Danish Cancer Society Research Center, Copenhagen, DenmarkDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Infectious Diseases Epidemiology and Modelling, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, DenmarkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology, Lazio Regional Health Service, ASL Roma 1, Rome, ItalySwiss Tropical and Public Health Institute, Basel, SwitzerlandInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, GermanyInstitute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the NetherlandsDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark; Center for Epidemiological Research, Nykøbing F Hospital, Nykøbing F, Denmark; Corresponding author at: Department of Public Health, University of Copenhagen, Copenhagen, Denmark.Background: Air pollution has been suggested as a risk factor for chronic obstructive pulmonary disease (COPD), but evidence is sparse and inconsistent. Objectives: We examined the association between long-term exposure to low-level air pollution and COPD incidence. Methods: Within the ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE) study, we pooled data from three cohorts, from Denmark and Sweden, with information on COPD hospital discharge diagnoses. Hybrid land use regression models were used to estimate annual mean concentrations of particulate matter with a diameter < 2.5 µm (PM2.5), nitrogen dioxide (NO2), and black carbon (BC) in 2010 at participants’ baseline residential addresses, which were analysed in relation to COPD incidence using Cox proportional hazards models. Results: Of 98,058 participants, 4,928 developed COPD during 16.6 years mean follow-up. The adjusted hazard ratios (HRs) and 95% confidence intervals for associations with COPD incidence were 1.17 (1.06, 1.29) per 5 µg/m3 for PM2.5, 1.11 (1.06, 1.16) per 10 µg/m3 for NO2, and 1.11 (1.06, 1.15) per 0.5 10−5m−1 for BC. Associations persisted in subset participants with PM2.5 or NO2 levels below current EU and US limit values and WHO guidelines, with no evidence for a threshold. HRs for NO2 and BC remained unchanged in two-pollutant models with PM2.5, whereas the HR for PM2.5 was attenuated to unity with NO2 or BC. Conclusions: Long-term exposure to low-level air pollution is associated with the development of COPD, even below current EU and US limit values and possibly WHO guidelines. Traffic-related pollutants NO2 and BC may be the most relevant.http://www.sciencedirect.com/science/article/pii/S0160412020322224Air pollutionCOPD incidenceLow-level exposure |