Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women
Childhood adversities (CAs) and infections may affect the timing of reproductive development. We examined the associations of indicators of CAs and exposure to tonsillitis and infectious mononucleosis (mono) with age at menarche. A multiethnic cohort of 400 women (ages 40–64 years) reported exposure...
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doaj-af0f8d35ea814716a9e63467340502df2021-04-13T23:00:53ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012021-04-01184080408010.3390/ijerph18084080Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of WomenAyana K. April-Sanders0Parisa Tehranifar1Erica Lee Argov2Shakira F. Suglia3Carmen B. Rodriguez4Jasmine A. McDonald5Division of Cardiovascular Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USADepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY 10032, USADepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY 10032, USADepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY 10032, USADepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY 10032, USADepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY 10032, USAChildhood adversities (CAs) and infections may affect the timing of reproductive development. We examined the associations of indicators of CAs and exposure to tonsillitis and infectious mononucleosis (mono) with age at menarche. A multiethnic cohort of 400 women (ages 40–64 years) reported exposure to parental maltreatment and maladjustment during childhood and any diagnosis of tonsillitis and/or mono; infections primarily acquired in early life and adolescence, respectively. We used linear and relative risk regression models to examine the associations of indicators of CAs individually and cumulatively, and history of tonsillitis/mono with an average age at menarche and early onset of menarche (<12 years of age). In multivariable models, histories of mental illness in the household (RR = 1.44, 95% CI: 1.01–2.06), and tonsillitis diagnosis (RR = 1.67, 95% CI: 1.20–2.33) were associated with early menarche (<12 years), and with an earlier average age at menarche by 7.1 months (95% CI: −1.15, −0.02) and 8.8 months (95% CI: −1.26, −0.20), respectively. Other adversities indicators, cumulative adversities, and mono were not statistically associated with menarcheal timing. These findings provided some support for the growing evidence that early life experiences may influence the reproductive development in girls.https://www.mdpi.com/1660-4601/18/8/4080menarcheracial and ethnic minorityimmigrantearly life |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ayana K. April-Sanders Parisa Tehranifar Erica Lee Argov Shakira F. Suglia Carmen B. Rodriguez Jasmine A. McDonald |
spellingShingle |
Ayana K. April-Sanders Parisa Tehranifar Erica Lee Argov Shakira F. Suglia Carmen B. Rodriguez Jasmine A. McDonald Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women International Journal of Environmental Research and Public Health menarche racial and ethnic minority immigrant early life |
author_facet |
Ayana K. April-Sanders Parisa Tehranifar Erica Lee Argov Shakira F. Suglia Carmen B. Rodriguez Jasmine A. McDonald |
author_sort |
Ayana K. April-Sanders |
title |
Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women |
title_short |
Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women |
title_full |
Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women |
title_fullStr |
Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women |
title_full_unstemmed |
Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women |
title_sort |
influence of childhood adversity and infection on timing of menarche in a multiethnic sample of women |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2021-04-01 |
description |
Childhood adversities (CAs) and infections may affect the timing of reproductive development. We examined the associations of indicators of CAs and exposure to tonsillitis and infectious mononucleosis (mono) with age at menarche. A multiethnic cohort of 400 women (ages 40–64 years) reported exposure to parental maltreatment and maladjustment during childhood and any diagnosis of tonsillitis and/or mono; infections primarily acquired in early life and adolescence, respectively. We used linear and relative risk regression models to examine the associations of indicators of CAs individually and cumulatively, and history of tonsillitis/mono with an average age at menarche and early onset of menarche (<12 years of age). In multivariable models, histories of mental illness in the household (RR = 1.44, 95% CI: 1.01–2.06), and tonsillitis diagnosis (RR = 1.67, 95% CI: 1.20–2.33) were associated with early menarche (<12 years), and with an earlier average age at menarche by 7.1 months (95% CI: −1.15, −0.02) and 8.8 months (95% CI: −1.26, −0.20), respectively. Other adversities indicators, cumulative adversities, and mono were not statistically associated with menarcheal timing. These findings provided some support for the growing evidence that early life experiences may influence the reproductive development in girls. |
topic |
menarche racial and ethnic minority immigrant early life |
url |
https://www.mdpi.com/1660-4601/18/8/4080 |
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