Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women

Childhood adversities (CAs) and infections may affect the timing of reproductive development. We examined the associations of indicators of CAs and exposure to tonsillitis and infectious mononucleosis (mono) with age at menarche. A multiethnic cohort of 400 women (ages 40–64 years) reported exposure...

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Main Authors: Ayana K. April-Sanders, Parisa Tehranifar, Erica Lee Argov, Shakira F. Suglia, Carmen B. Rodriguez, Jasmine A. McDonald
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Environmental Research and Public Health
Subjects:
Online Access:https://www.mdpi.com/1660-4601/18/8/4080
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spelling doaj-af0f8d35ea814716a9e63467340502df2021-04-13T23:00:53ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012021-04-01184080408010.3390/ijerph18084080Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of WomenAyana K. April-Sanders0Parisa Tehranifar1Erica Lee Argov2Shakira F. Suglia3Carmen B. Rodriguez4Jasmine A. McDonald5Division of Cardiovascular Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USADepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY 10032, USADepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY 10032, USADepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY 10032, USADepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY 10032, USADepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY 10032, USAChildhood adversities (CAs) and infections may affect the timing of reproductive development. We examined the associations of indicators of CAs and exposure to tonsillitis and infectious mononucleosis (mono) with age at menarche. A multiethnic cohort of 400 women (ages 40–64 years) reported exposure to parental maltreatment and maladjustment during childhood and any diagnosis of tonsillitis and/or mono; infections primarily acquired in early life and adolescence, respectively. We used linear and relative risk regression models to examine the associations of indicators of CAs individually and cumulatively, and history of tonsillitis/mono with an average age at menarche and early onset of menarche (<12 years of age). In multivariable models, histories of mental illness in the household (RR = 1.44, 95% CI: 1.01–2.06), and tonsillitis diagnosis (RR = 1.67, 95% CI: 1.20–2.33) were associated with early menarche (<12 years), and with an earlier average age at menarche by 7.1 months (95% CI: −1.15, −0.02) and 8.8 months (95% CI: −1.26, −0.20), respectively. Other adversities indicators, cumulative adversities, and mono were not statistically associated with menarcheal timing. These findings provided some support for the growing evidence that early life experiences may influence the reproductive development in girls.https://www.mdpi.com/1660-4601/18/8/4080menarcheracial and ethnic minorityimmigrantearly life
collection DOAJ
language English
format Article
sources DOAJ
author Ayana K. April-Sanders
Parisa Tehranifar
Erica Lee Argov
Shakira F. Suglia
Carmen B. Rodriguez
Jasmine A. McDonald
spellingShingle Ayana K. April-Sanders
Parisa Tehranifar
Erica Lee Argov
Shakira F. Suglia
Carmen B. Rodriguez
Jasmine A. McDonald
Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women
International Journal of Environmental Research and Public Health
menarche
racial and ethnic minority
immigrant
early life
author_facet Ayana K. April-Sanders
Parisa Tehranifar
Erica Lee Argov
Shakira F. Suglia
Carmen B. Rodriguez
Jasmine A. McDonald
author_sort Ayana K. April-Sanders
title Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women
title_short Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women
title_full Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women
title_fullStr Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women
title_full_unstemmed Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women
title_sort influence of childhood adversity and infection on timing of menarche in a multiethnic sample of women
publisher MDPI AG
series International Journal of Environmental Research and Public Health
issn 1661-7827
1660-4601
publishDate 2021-04-01
description Childhood adversities (CAs) and infections may affect the timing of reproductive development. We examined the associations of indicators of CAs and exposure to tonsillitis and infectious mononucleosis (mono) with age at menarche. A multiethnic cohort of 400 women (ages 40–64 years) reported exposure to parental maltreatment and maladjustment during childhood and any diagnosis of tonsillitis and/or mono; infections primarily acquired in early life and adolescence, respectively. We used linear and relative risk regression models to examine the associations of indicators of CAs individually and cumulatively, and history of tonsillitis/mono with an average age at menarche and early onset of menarche (<12 years of age). In multivariable models, histories of mental illness in the household (RR = 1.44, 95% CI: 1.01–2.06), and tonsillitis diagnosis (RR = 1.67, 95% CI: 1.20–2.33) were associated with early menarche (<12 years), and with an earlier average age at menarche by 7.1 months (95% CI: −1.15, −0.02) and 8.8 months (95% CI: −1.26, −0.20), respectively. Other adversities indicators, cumulative adversities, and mono were not statistically associated with menarcheal timing. These findings provided some support for the growing evidence that early life experiences may influence the reproductive development in girls.
topic menarche
racial and ethnic minority
immigrant
early life
url https://www.mdpi.com/1660-4601/18/8/4080
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