Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model
Abstract Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry...
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Nature Publishing Group
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-80532-6 |
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DOAJ |
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Péter J. Hegyi Alexandra Soós Emese Tóth Attila Ébert Viktória Venglovecz Katalin Márta Péter Mátrai Alexandra Mikó Judit Bajor Patrícia Sarlós Áron Vincze Adrienn Halász Ferenc Izbéki Zoltán Szepes László Czakó György Kovács Mária Papp Zsolt Dubravcsik Márta Varga József Hamvas Balázs C. Németh Melania Macarie Ali Tüzün Ince Dmitry S. Bordin Elena A. Dubtsova Mariya A. Kiryukova Igor E. Khatkov Tanya Bideeva Artautas Mickevicius Elena Ramírez-Maldonado Ville Sallinen Bálint Erőss Dániel Pécsi Andrea Szentesi Andrea Párniczky László Tiszlavicz Péter Hegyi |
| spellingShingle |
Péter J. Hegyi Alexandra Soós Emese Tóth Attila Ébert Viktória Venglovecz Katalin Márta Péter Mátrai Alexandra Mikó Judit Bajor Patrícia Sarlós Áron Vincze Adrienn Halász Ferenc Izbéki Zoltán Szepes László Czakó György Kovács Mária Papp Zsolt Dubravcsik Márta Varga József Hamvas Balázs C. Németh Melania Macarie Ali Tüzün Ince Dmitry S. Bordin Elena A. Dubtsova Mariya A. Kiryukova Igor E. Khatkov Tanya Bideeva Artautas Mickevicius Elena Ramírez-Maldonado Ville Sallinen Bálint Erőss Dániel Pécsi Andrea Szentesi Andrea Párniczky László Tiszlavicz Péter Hegyi Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model Scientific Reports |
| author_facet |
Péter J. Hegyi Alexandra Soós Emese Tóth Attila Ébert Viktória Venglovecz Katalin Márta Péter Mátrai Alexandra Mikó Judit Bajor Patrícia Sarlós Áron Vincze Adrienn Halász Ferenc Izbéki Zoltán Szepes László Czakó György Kovács Mária Papp Zsolt Dubravcsik Márta Varga József Hamvas Balázs C. Németh Melania Macarie Ali Tüzün Ince Dmitry S. Bordin Elena A. Dubtsova Mariya A. Kiryukova Igor E. Khatkov Tanya Bideeva Artautas Mickevicius Elena Ramírez-Maldonado Ville Sallinen Bálint Erőss Dániel Pécsi Andrea Szentesi Andrea Párniczky László Tiszlavicz Péter Hegyi |
| author_sort |
Péter J. Hegyi |
| title |
Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model |
| title_short |
Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model |
| title_full |
Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model |
| title_fullStr |
Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model |
| title_full_unstemmed |
Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model |
| title_sort |
evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model |
| publisher |
Nature Publishing Group |
| series |
Scientific Reports |
| issn |
2045-2322 |
| publishDate |
2021-01-01 |
| description |
Abstract Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare. |
| url |
https://doi.org/10.1038/s41598-020-80532-6 |
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doaj-af1cfbbd87af4a9bbd62d7ad8b62eeb62021-01-17T12:43:53ZengNature Publishing GroupScientific Reports2045-23222021-01-0111111410.1038/s41598-020-80532-6Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal modelPéter J. Hegyi0Alexandra Soós1Emese Tóth2Attila Ébert3Viktória Venglovecz4Katalin Márta5Péter Mátrai6Alexandra Mikó7Judit Bajor8Patrícia Sarlós9Áron Vincze10Adrienn Halász11Ferenc Izbéki12Zoltán Szepes13László Czakó14György Kovács15Mária Papp16Zsolt Dubravcsik17Márta Varga18József Hamvas19Balázs C. Németh20Melania Macarie21Ali Tüzün Ince22Dmitry S. Bordin23Elena A. Dubtsova24Mariya A. Kiryukova25Igor E. Khatkov26Tanya Bideeva27Artautas Mickevicius28Elena Ramírez-Maldonado29Ville Sallinen30Bálint Erőss31Dániel Pécsi32Andrea Szentesi33Andrea Párniczky34László Tiszlavicz35Péter Hegyi36Institute for Translational Medicine, Medical School, Szentágothai Research Centre, University of PécsDepartment of Medicine, University of SzegedDepartment of Medicine, University of SzegedDepartment of Pharmacology and PharmacotherapyDepartment of Pharmacology and PharmacotherapyInstitute for Translational Medicine, Medical School, Szentágothai Research Centre, University of PécsInstitute for Translational Medicine, Medical School, Szentágothai Research Centre, University of PécsInstitute for Translational Medicine, Medical School, Szentágothai Research Centre, University of PécsDivision of Gastroenterology, First Department of Medicine, Medical School, University of PécsDivision of Gastroenterology, First Department of Medicine, Medical School, University of PécsDivision of Gastroenterology, First Department of Medicine, Medical School, University of PécsSzent György Teaching Hospital of County FejérSzent György Teaching Hospital of County FejérDepartment of Medicine, University of SzegedDepartment of Medicine, University of SzegedDepartment of Internal Medicine, Division of Gastroenterology, University of DebrecenDepartment of Internal Medicine, Division of Gastroenterology, University of DebrecenBács-Kiskun County HospitalDr. Réthy Pál HospitalPeterfy Hospital and Trauma, Trauma Emergency RoomDepartment of Medicine, University of SzegedCounty Emergency Clinical Hospital - Gastroenterology and, University of Medicine, Pharmacy, Sciences and TechnologySchool of Medicine, Hospital of Bezmialem Vakif UniversityA.S. Loginov Moscow Clinical Scientific CenterA.S. Loginov Moscow Clinical Scientific CenterA.S. Loginov Moscow Clinical Scientific CenterA.S. Loginov Moscow Clinical Scientific CenterSemashko Central Clinical HospitalClinic of Gastroenterology, Nephrourology and Abdominal Surgery, Faculty of Medicine, Vilnius UniversityConsorci Sanitari del Garraf, Sant Pere de RibesDepartment of Abdominal Surgery, University of Helsinki and Helsinki University HospitalInstitute for Translational Medicine, Medical School, Szentágothai Research Centre, University of PécsInstitute for Translational Medicine, Medical School, Szentágothai Research Centre, University of PécsInstitute for Translational Medicine, Medical School, Szentágothai Research Centre, University of PécsInstitute for Translational Medicine, Medical School, Szentágothai Research Centre, University of PécsDepartment of Pathology, University of SzegedInstitute for Translational Medicine, Medical School, Szentágothai Research Centre, University of PécsAbstract Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.https://doi.org/10.1038/s41598-020-80532-6 |