Sequence comparison of six human microRNAs genes between tuberculosis patients and healthy individuals
Objective/Background: MicroRNAs (miRNAs) play an important role in diseases development. Therefore, human miRNAs may be able to inhibit the survival of Mycobacterium tuberculosis (Mtb) in the human host by targeting critical genes of the pathogen. Mutations within miRNAs can alter their target selec...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2015-01-01
|
Series: | International Journal of Mycobacteriology |
Subjects: | |
Online Access: | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=4;spage=341;epage=346;aulast=Amila |
id |
doaj-af1e9bc37ce9440b86d8e8c0d2e7729e |
---|---|
record_format |
Article |
spelling |
doaj-af1e9bc37ce9440b86d8e8c0d2e7729e2020-11-24T22:34:21ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2015-01-014434134610.1016/j.ijmyco.2015.06.009Sequence comparison of six human microRNAs genes between tuberculosis patients and healthy individualsA AmilaA AcostaM E SarmientoSiti SuraiyaZ ZafarinaS PanneerchelvamM N NorazmiObjective/Background: MicroRNAs (miRNAs) play an important role in diseases development. Therefore, human miRNAs may be able to inhibit the survival of Mycobacterium tuberculosis (Mtb) in the human host by targeting critical genes of the pathogen. Mutations within miRNAs can alter their target selection, thereby preventing them from inhibiting Mtb genes, thus increasing host susceptibility to the disease. Methods: This study was undertaken to investigate the genetic association of pulmonary tuberculosis (TB) with six human miRNAs genes, namely, hsa-miR-370, hsa-miR-520d, hsa-miR-154, hsa-miR-497, hsa-miR-758, and hsa-miR-593, which have been predicted to interact with Mtb genes. The objective of the study was to determine the possible sequence variation of selected miRNA genes that are potentially associated with the inhibition of critical Mtb genes in TB patients. Results: The study did not show differences in the sequences compared with healthy individuals without antecedents of TB. Conclusion: This result could have been influenced by the sample size and the selection of miRNA genes, which need to be addressed in future studies.http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=4;spage=341;epage=346;aulast=AmilamicroRNAsMycobacterium tuberculosisTuberculosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A Amila A Acosta M E Sarmiento Siti Suraiya Z Zafarina S Panneerchelvam M N Norazmi |
spellingShingle |
A Amila A Acosta M E Sarmiento Siti Suraiya Z Zafarina S Panneerchelvam M N Norazmi Sequence comparison of six human microRNAs genes between tuberculosis patients and healthy individuals International Journal of Mycobacteriology microRNAs Mycobacterium tuberculosis Tuberculosis |
author_facet |
A Amila A Acosta M E Sarmiento Siti Suraiya Z Zafarina S Panneerchelvam M N Norazmi |
author_sort |
A Amila |
title |
Sequence comparison of six human microRNAs genes between tuberculosis patients and healthy individuals |
title_short |
Sequence comparison of six human microRNAs genes between tuberculosis patients and healthy individuals |
title_full |
Sequence comparison of six human microRNAs genes between tuberculosis patients and healthy individuals |
title_fullStr |
Sequence comparison of six human microRNAs genes between tuberculosis patients and healthy individuals |
title_full_unstemmed |
Sequence comparison of six human microRNAs genes between tuberculosis patients and healthy individuals |
title_sort |
sequence comparison of six human micrornas genes between tuberculosis patients and healthy individuals |
publisher |
Wolters Kluwer Medknow Publications |
series |
International Journal of Mycobacteriology |
issn |
2212-5531 2212-554X |
publishDate |
2015-01-01 |
description |
Objective/Background: MicroRNAs (miRNAs) play an important role in diseases development. Therefore, human miRNAs may be able to inhibit the survival of Mycobacterium tuberculosis (Mtb) in the human host by targeting critical genes of the pathogen. Mutations within miRNAs can alter their target selection, thereby preventing them from inhibiting Mtb genes, thus increasing host susceptibility to the disease.
Methods: This study was undertaken to investigate the genetic association of pulmonary tuberculosis (TB) with six human miRNAs genes, namely, hsa-miR-370, hsa-miR-520d, hsa-miR-154, hsa-miR-497, hsa-miR-758, and hsa-miR-593, which have been predicted to interact with Mtb genes. The objective of the study was to determine the possible sequence variation of selected miRNA genes that are potentially associated with the inhibition of critical Mtb genes in TB patients.
Results: The study did not show differences in the sequences compared with healthy individuals without antecedents of TB.
Conclusion: This result could have been influenced by the sample size and the selection of miRNA genes, which need to be addressed in future studies. |
topic |
microRNAs Mycobacterium tuberculosis Tuberculosis |
url |
http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=4;spage=341;epage=346;aulast=Amila |
work_keys_str_mv |
AT aamila sequencecomparisonofsixhumanmicrornasgenesbetweentuberculosispatientsandhealthyindividuals AT aacosta sequencecomparisonofsixhumanmicrornasgenesbetweentuberculosispatientsandhealthyindividuals AT mesarmiento sequencecomparisonofsixhumanmicrornasgenesbetweentuberculosispatientsandhealthyindividuals AT sitisuraiya sequencecomparisonofsixhumanmicrornasgenesbetweentuberculosispatientsandhealthyindividuals AT zzafarina sequencecomparisonofsixhumanmicrornasgenesbetweentuberculosispatientsandhealthyindividuals AT spanneerchelvam sequencecomparisonofsixhumanmicrornasgenesbetweentuberculosispatientsandhealthyindividuals AT mnnorazmi sequencecomparisonofsixhumanmicrornasgenesbetweentuberculosispatientsandhealthyindividuals |
_version_ |
1725728038175375360 |