Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis

Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis

Abstract Alteration in the excitatory/inhibitory neuronal balance is believed to be the underlying mechanism of epileptogenesis. Based on this theory, GABAergic interneurons are regarded as the primary inhibitory neurons, whose failure of action permits hyperactivity in the epileptic circuitry. As a...

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Bibliographic Details
Main Authors: Hui Ye, Stephanie Kaszuba
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Journal of Biomedical Science
Subjects:
Epilepsy
GABAergic interneurons
Optogenetics
Online Access:http://link.springer.com/article/10.1186/s12929-017-0399-8

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