The antibacterial activity of selected plants towards resistant bacteria isolated from clinical specimens
Objective: To evaluate the antibacterial activity of eight plants against methicillin-resistant Staphylococcus aureus (MRSA), extended spectrum beta-lactamase and carbapenemase-resistant Enterobacteriaceae, which are the most prevalent causes of infections in inpatients. Methods: The antibacterial a...
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doaj-af37f3626bf142b6893d5302b2cd0acb2020-11-24T22:33:33ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912016-01-0161161910.1016/j.apjtb.2015.08.003The antibacterial activity of selected plants towards resistant bacteria isolated from clinical specimensPratiwi WikaningtyasElin Yulinah SukandarObjective: To evaluate the antibacterial activity of eight plants against methicillin-resistant Staphylococcus aureus (MRSA), extended spectrum beta-lactamase and carbapenemase-resistant Enterobacteriaceae, which are the most prevalent causes of infections in inpatients. Methods: The antibacterial activity was calculated based on the minimum inhibitory concentration using Mueller–Hinton broth in a microdilution method. Results: The best antibacterial activity, calculated as minimum inhibitory concentration values, against MRSA was shown by the Kaempferia pandurata (Roxb) (K. pandurata) extract (256 μg/mL) and the Senna alata (S. alata) extract (512 μg/mL). Phytochemical screening of dried S. alata leaf and its extract showed the presence of flavonoids, alkaloids, saponins, quinones, tannins and sterols, while dried K. pandurata and its extract only showed the presence of flavonoids and sterols/triterpenoids. Conclusions: K. pandurata and S. alata have the potential to be developed as antibacterial agents, especially against MRSA strain, but further in vivo research and discovery of the mode of its action are still needed to shed light on the effects.http://www.sciencedirect.com/science/article/pii/S2221169115002415Medicinal plantsAntibacterial activityMinimum inhibitory concentrationResistance bacteriaSecondary metabolites |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pratiwi Wikaningtyas Elin Yulinah Sukandar |
spellingShingle |
Pratiwi Wikaningtyas Elin Yulinah Sukandar The antibacterial activity of selected plants towards resistant bacteria isolated from clinical specimens Asian Pacific Journal of Tropical Biomedicine Medicinal plants Antibacterial activity Minimum inhibitory concentration Resistance bacteria Secondary metabolites |
author_facet |
Pratiwi Wikaningtyas Elin Yulinah Sukandar |
author_sort |
Pratiwi Wikaningtyas |
title |
The antibacterial activity of selected plants towards resistant bacteria isolated from clinical specimens |
title_short |
The antibacterial activity of selected plants towards resistant bacteria isolated from clinical specimens |
title_full |
The antibacterial activity of selected plants towards resistant bacteria isolated from clinical specimens |
title_fullStr |
The antibacterial activity of selected plants towards resistant bacteria isolated from clinical specimens |
title_full_unstemmed |
The antibacterial activity of selected plants towards resistant bacteria isolated from clinical specimens |
title_sort |
antibacterial activity of selected plants towards resistant bacteria isolated from clinical specimens |
publisher |
Wolters Kluwer Medknow Publications |
series |
Asian Pacific Journal of Tropical Biomedicine |
issn |
2221-1691 |
publishDate |
2016-01-01 |
description |
Objective: To evaluate the antibacterial activity of eight plants against methicillin-resistant Staphylococcus aureus (MRSA), extended spectrum beta-lactamase and carbapenemase-resistant Enterobacteriaceae, which are the most prevalent causes of infections in inpatients.
Methods: The antibacterial activity was calculated based on the minimum inhibitory concentration using Mueller–Hinton broth in a microdilution method.
Results: The best antibacterial activity, calculated as minimum inhibitory concentration values, against MRSA was shown by the Kaempferia pandurata (Roxb) (K. pandurata) extract (256 μg/mL) and the Senna alata (S. alata) extract (512 μg/mL). Phytochemical screening of dried S. alata leaf and its extract showed the presence of flavonoids, alkaloids, saponins, quinones, tannins and sterols, while dried K. pandurata and its extract only showed the presence of flavonoids and sterols/triterpenoids.
Conclusions: K. pandurata and S. alata have the potential to be developed as antibacterial agents, especially against MRSA strain, but further in vivo research and discovery of the mode of its action are still needed to shed light on the effects. |
topic |
Medicinal plants Antibacterial activity Minimum inhibitory concentration Resistance bacteria Secondary metabolites |
url |
http://www.sciencedirect.com/science/article/pii/S2221169115002415 |
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