Green biosynthesis of superparamagnetic magnetite Fe3O4 nanoparticles and biomedical applications in targeted anticancer drug delivery system: A review
This review discussed about the green biosynthesis of magnetite nanoparticles (Fe3O4-NPs) and the biomedical applications, which mainly focus on the targeted anticancer drug delivery. Fe3O4-NPs have been studied and proved that Fe3O4-NPs can be used in various fields of application, due to “superpar...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-01-01
|
Series: | Arabian Journal of Chemistry |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535218301023 |
id |
doaj-af3cb8c67248486c8dd64626fc5a9e83 |
---|---|
record_format |
Article |
spelling |
doaj-af3cb8c67248486c8dd64626fc5a9e832020-11-25T02:21:36ZengElsevierArabian Journal of Chemistry1878-53522020-01-0113122872308Green biosynthesis of superparamagnetic magnetite Fe3O4 nanoparticles and biomedical applications in targeted anticancer drug delivery system: A reviewYen Pin Yew0Kamyar Shameli1Mikio Miyake2Nurul Bahiyah Bt Ahmad Khairudin3Shaza Eva Bt Mohamad4Takeru Naiki5Kar Xin Lee6Department of Environmental Engineering and Green Technology, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, MalaysiaDepartment of Environmental Engineering and Green Technology, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia; Corresponding author.Japan Advanced Institute of Science and Technology (JAIST), JapanDepartment of Environmental Engineering and Green Technology, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, MalaysiaDepartment of Environmental Engineering and Green Technology, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, MalaysiaDepartment of Biomedical Engineering, Faculty of Engineering, Okayama University of Science, JapanDepartment of Environmental Engineering and Green Technology, Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, MalaysiaThis review discussed about the green biosynthesis of magnetite nanoparticles (Fe3O4-NPs) and the biomedical applications, which mainly focus on the targeted anticancer drug delivery. Fe3O4-NPs have been studied and proved that Fe3O4-NPs can be used in various fields of application, due to “superparamagnetic” property that Fe3O4-NPs possessed. In targeted drug delivery system, drug loaded Fe3O4-NPs can accumulate at the tumor site by the aid of external magnetic field. This can increase the effectiveness of drug release to the tumor site and vanquish cancer cells without harming healthy cells. In order to apply Fe3O4-NPs in human body, Fe3O4-NPs have to be biocompatible and biodegradable to minimize the toxicity. So, green biosynthesis plays a crucial role as the biosynthesized Fe3O4-NPs is safe to be consumed by human because the materials used are from biological routes, such as plant extract and natural polymer. However, biosynthesis using plant extract is the most popular among them all as plant extract can act as both reducing and stabilizing agents in the synthesizing process of nanoparticles. This approach is not merely simple, yet economic and less waste production, which is environmental friendly. Several biomedical applications of Fe3O4-NPs are included in this review, but anticancer drug delivery study is discussed in detail. The criteria for Fe3O4-NPs to be used as drug delivery vehicle are discussed so as to study the optimum condition of Fe3O4-NPs in drug delivery application. Many researches showed the promising results of Fe3O4-NPs in treating cancer cells via in vitro study. Hence, this review is significant which summarize the vital points of Fe3O4-NPs in targeted anticancer drug delivery system. Conclusions have been made according to the literature reviewed and some points of view were proposed for future study. Keywords: Green biosynthesis, Superparamagnetic, Magnetite nanoparticle, Anticancer, Targeted drug deliveryhttp://www.sciencedirect.com/science/article/pii/S1878535218301023 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yen Pin Yew Kamyar Shameli Mikio Miyake Nurul Bahiyah Bt Ahmad Khairudin Shaza Eva Bt Mohamad Takeru Naiki Kar Xin Lee |
spellingShingle |
Yen Pin Yew Kamyar Shameli Mikio Miyake Nurul Bahiyah Bt Ahmad Khairudin Shaza Eva Bt Mohamad Takeru Naiki Kar Xin Lee Green biosynthesis of superparamagnetic magnetite Fe3O4 nanoparticles and biomedical applications in targeted anticancer drug delivery system: A review Arabian Journal of Chemistry |
author_facet |
Yen Pin Yew Kamyar Shameli Mikio Miyake Nurul Bahiyah Bt Ahmad Khairudin Shaza Eva Bt Mohamad Takeru Naiki Kar Xin Lee |
author_sort |
Yen Pin Yew |
title |
Green biosynthesis of superparamagnetic magnetite Fe3O4 nanoparticles and biomedical applications in targeted anticancer drug delivery system: A review |
title_short |
Green biosynthesis of superparamagnetic magnetite Fe3O4 nanoparticles and biomedical applications in targeted anticancer drug delivery system: A review |
title_full |
Green biosynthesis of superparamagnetic magnetite Fe3O4 nanoparticles and biomedical applications in targeted anticancer drug delivery system: A review |
title_fullStr |
Green biosynthesis of superparamagnetic magnetite Fe3O4 nanoparticles and biomedical applications in targeted anticancer drug delivery system: A review |
title_full_unstemmed |
Green biosynthesis of superparamagnetic magnetite Fe3O4 nanoparticles and biomedical applications in targeted anticancer drug delivery system: A review |
title_sort |
green biosynthesis of superparamagnetic magnetite fe3o4 nanoparticles and biomedical applications in targeted anticancer drug delivery system: a review |
publisher |
Elsevier |
series |
Arabian Journal of Chemistry |
issn |
1878-5352 |
publishDate |
2020-01-01 |
description |
This review discussed about the green biosynthesis of magnetite nanoparticles (Fe3O4-NPs) and the biomedical applications, which mainly focus on the targeted anticancer drug delivery. Fe3O4-NPs have been studied and proved that Fe3O4-NPs can be used in various fields of application, due to “superparamagnetic” property that Fe3O4-NPs possessed. In targeted drug delivery system, drug loaded Fe3O4-NPs can accumulate at the tumor site by the aid of external magnetic field. This can increase the effectiveness of drug release to the tumor site and vanquish cancer cells without harming healthy cells. In order to apply Fe3O4-NPs in human body, Fe3O4-NPs have to be biocompatible and biodegradable to minimize the toxicity. So, green biosynthesis plays a crucial role as the biosynthesized Fe3O4-NPs is safe to be consumed by human because the materials used are from biological routes, such as plant extract and natural polymer. However, biosynthesis using plant extract is the most popular among them all as plant extract can act as both reducing and stabilizing agents in the synthesizing process of nanoparticles. This approach is not merely simple, yet economic and less waste production, which is environmental friendly. Several biomedical applications of Fe3O4-NPs are included in this review, but anticancer drug delivery study is discussed in detail. The criteria for Fe3O4-NPs to be used as drug delivery vehicle are discussed so as to study the optimum condition of Fe3O4-NPs in drug delivery application. Many researches showed the promising results of Fe3O4-NPs in treating cancer cells via in vitro study. Hence, this review is significant which summarize the vital points of Fe3O4-NPs in targeted anticancer drug delivery system. Conclusions have been made according to the literature reviewed and some points of view were proposed for future study. Keywords: Green biosynthesis, Superparamagnetic, Magnetite nanoparticle, Anticancer, Targeted drug delivery |
url |
http://www.sciencedirect.com/science/article/pii/S1878535218301023 |
work_keys_str_mv |
AT yenpinyew greenbiosynthesisofsuperparamagneticmagnetitefe3o4nanoparticlesandbiomedicalapplicationsintargetedanticancerdrugdeliverysystemareview AT kamyarshameli greenbiosynthesisofsuperparamagneticmagnetitefe3o4nanoparticlesandbiomedicalapplicationsintargetedanticancerdrugdeliverysystemareview AT mikiomiyake greenbiosynthesisofsuperparamagneticmagnetitefe3o4nanoparticlesandbiomedicalapplicationsintargetedanticancerdrugdeliverysystemareview AT nurulbahiyahbtahmadkhairudin greenbiosynthesisofsuperparamagneticmagnetitefe3o4nanoparticlesandbiomedicalapplicationsintargetedanticancerdrugdeliverysystemareview AT shazaevabtmohamad greenbiosynthesisofsuperparamagneticmagnetitefe3o4nanoparticlesandbiomedicalapplicationsintargetedanticancerdrugdeliverysystemareview AT takerunaiki greenbiosynthesisofsuperparamagneticmagnetitefe3o4nanoparticlesandbiomedicalapplicationsintargetedanticancerdrugdeliverysystemareview AT karxinlee greenbiosynthesisofsuperparamagneticmagnetitefe3o4nanoparticlesandbiomedicalapplicationsintargetedanticancerdrugdeliverysystemareview |
_version_ |
1724865194159505408 |