The efficacy and safety of irinotecan cisplatin and mitomycin chemotherapy in sunitinib pre-treated metastatic clear cell renal cancer
Thomas Powles, Siobhan McFaul, Justin Stebbing, Peter Wilson, Tim Oliver, Naomi Tranter, Jonathan ShamashDepartment of Medical Oncology, St Bartholomew’s Hospital, London, United KingdomBackground: Sunitinib is widely used as first-line treatment for metastatic clear cell...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2008-09-01
|
Series: | OncoTargets and Therapy |
Online Access: | http://www.dovepress.com/the-efficacy-and-safety-of-irinotecan-cisplatin-and-mitomycin-chemothe-a2321 |
id |
doaj-af42624f6fea47ff8a31df121df140b7 |
---|---|
record_format |
Article |
spelling |
doaj-af42624f6fea47ff8a31df121df140b72020-11-24T23:46:36ZengDove Medical PressOncoTargets and Therapy1178-69302008-09-012008default3539The efficacy and safety of irinotecan cisplatin and mitomycin chemotherapy in sunitinib pre-treated metastatic clear cell renal cancerThomas PowlesSiobhan McFaulJustin StebbingPeter WilsonTim Oliver et alThomas Powles, Siobhan McFaul, Justin Stebbing, Peter Wilson, Tim Oliver, Naomi Tranter, Jonathan ShamashDepartment of Medical Oncology, St Bartholomew’s Hospital, London, United KingdomBackground: Sunitinib is widely used as first-line treatment for metastatic clear cell renal cancer (MCRC). No reports are known of treatment after sunitinib failure. As irinotecan, cisplatin, and mitomycin-C (IPM) chemotherapy has been reported to influence MCRC after progression on cytokine therapy, we report on the outcome of 11 patients treated with IPM after sunitinib failure.Patients and methods: Eleven patients with progression of disease on sunitinib therapy were treated with 4, monthly cycles of monthly IPM.Results: Nine out of 11 patients progressed during IPM therapy. The median time to progression was 1.4 months (95% CI: 0.7–2.1 months), while the overall survival was 4.2 months (95% CI: 0.9–2.3). Overall 10 patients have died of progressive renal cancer. One patient had a radiological response to therapy and remains progression free 11 months after treatment. Four of the 10 patients required a dose reduction for grade 3 or 4 toxicities.Conclusions: IPM alone does not appear to benefit patients with MCRC who previously progressed during sunitinib therapy. The median progression-free survival and overall survival for these patients is short.Keywords: renal cancer, chemotherapy, sunitinib http://www.dovepress.com/the-efficacy-and-safety-of-irinotecan-cisplatin-and-mitomycin-chemothe-a2321 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thomas Powles Siobhan McFaul Justin Stebbing Peter Wilson Tim Oliver et al |
spellingShingle |
Thomas Powles Siobhan McFaul Justin Stebbing Peter Wilson Tim Oliver et al The efficacy and safety of irinotecan cisplatin and mitomycin chemotherapy in sunitinib pre-treated metastatic clear cell renal cancer OncoTargets and Therapy |
author_facet |
Thomas Powles Siobhan McFaul Justin Stebbing Peter Wilson Tim Oliver et al |
author_sort |
Thomas Powles |
title |
The efficacy and safety of irinotecan cisplatin and mitomycin chemotherapy in sunitinib pre-treated metastatic clear cell renal cancer |
title_short |
The efficacy and safety of irinotecan cisplatin and mitomycin chemotherapy in sunitinib pre-treated metastatic clear cell renal cancer |
title_full |
The efficacy and safety of irinotecan cisplatin and mitomycin chemotherapy in sunitinib pre-treated metastatic clear cell renal cancer |
title_fullStr |
The efficacy and safety of irinotecan cisplatin and mitomycin chemotherapy in sunitinib pre-treated metastatic clear cell renal cancer |
title_full_unstemmed |
The efficacy and safety of irinotecan cisplatin and mitomycin chemotherapy in sunitinib pre-treated metastatic clear cell renal cancer |
title_sort |
efficacy and safety of irinotecan cisplatin and mitomycin chemotherapy in sunitinib pre-treated metastatic clear cell renal cancer |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2008-09-01 |
description |
Thomas Powles, Siobhan McFaul, Justin Stebbing, Peter Wilson, Tim Oliver, Naomi Tranter, Jonathan ShamashDepartment of Medical Oncology, St Bartholomew’s Hospital, London, United KingdomBackground: Sunitinib is widely used as first-line treatment for metastatic clear cell renal cancer (MCRC). No reports are known of treatment after sunitinib failure. As irinotecan, cisplatin, and mitomycin-C (IPM) chemotherapy has been reported to influence MCRC after progression on cytokine therapy, we report on the outcome of 11 patients treated with IPM after sunitinib failure.Patients and methods: Eleven patients with progression of disease on sunitinib therapy were treated with 4, monthly cycles of monthly IPM.Results: Nine out of 11 patients progressed during IPM therapy. The median time to progression was 1.4 months (95% CI: 0.7–2.1 months), while the overall survival was 4.2 months (95% CI: 0.9–2.3). Overall 10 patients have died of progressive renal cancer. One patient had a radiological response to therapy and remains progression free 11 months after treatment. Four of the 10 patients required a dose reduction for grade 3 or 4 toxicities.Conclusions: IPM alone does not appear to benefit patients with MCRC who previously progressed during sunitinib therapy. The median progression-free survival and overall survival for these patients is short.Keywords: renal cancer, chemotherapy, sunitinib |
url |
http://www.dovepress.com/the-efficacy-and-safety-of-irinotecan-cisplatin-and-mitomycin-chemothe-a2321 |
work_keys_str_mv |
AT thomaspowles theefficacyandsafetyofirinotecancisplatinandmitomycinchemotherapyinsunitinibpretreatedmetastaticclearcellrenalcancer AT siobhanmcfaul theefficacyandsafetyofirinotecancisplatinandmitomycinchemotherapyinsunitinibpretreatedmetastaticclearcellrenalcancer AT justinstebbing theefficacyandsafetyofirinotecancisplatinandmitomycinchemotherapyinsunitinibpretreatedmetastaticclearcellrenalcancer AT peterwilson theefficacyandsafetyofirinotecancisplatinandmitomycinchemotherapyinsunitinibpretreatedmetastaticclearcellrenalcancer AT timoliveretal theefficacyandsafetyofirinotecancisplatinandmitomycinchemotherapyinsunitinibpretreatedmetastaticclearcellrenalcancer AT thomaspowles efficacyandsafetyofirinotecancisplatinandmitomycinchemotherapyinsunitinibpretreatedmetastaticclearcellrenalcancer AT siobhanmcfaul efficacyandsafetyofirinotecancisplatinandmitomycinchemotherapyinsunitinibpretreatedmetastaticclearcellrenalcancer AT justinstebbing efficacyandsafetyofirinotecancisplatinandmitomycinchemotherapyinsunitinibpretreatedmetastaticclearcellrenalcancer AT peterwilson efficacyandsafetyofirinotecancisplatinandmitomycinchemotherapyinsunitinibpretreatedmetastaticclearcellrenalcancer AT timoliveretal efficacyandsafetyofirinotecancisplatinandmitomycinchemotherapyinsunitinibpretreatedmetastaticclearcellrenalcancer |
_version_ |
1725493245381705728 |