Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease
Delta-secretases are associated with Alzheimer’s disease (AD) as they cleave both amyloid precursor protein and tau. Here the authors develop a series of orally bioactive small molecule delta-secretase inhibitors and report its therapeutic effects in mouse models of AD.
Bibliographic Details
Main Authors: |
Zhentao Zhang,
Obiamaka Obianyo,
Elfriede Dall,
Yuhong Du,
Haian Fu,
Xia Liu,
Seong Su Kang,
Mingke Song,
Shan-Ping Yu,
Chiara Cabrele,
Mario Schubert,
Xiaoguang Li,
Jian-Zhi Wang,
Hans Brandstetter,
Keqiang Ye |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2017-03-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms14740
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