Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease
Delta-secretases are associated with Alzheimer’s disease (AD) as they cleave both amyloid precursor protein and tau. Here the authors develop a series of orally bioactive small molecule delta-secretase inhibitors and report its therapeutic effects in mouse models of AD.
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14740 |
| id |
doaj-af4749718ac94cb988dc9847eb692495 |
|---|---|
| record_format |
Article |
| spelling |
doaj-af4749718ac94cb988dc9847eb6924952021-05-11T07:37:18ZengNature Publishing GroupNature Communications2041-17232017-03-018111710.1038/ncomms14740Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s diseaseZhentao Zhang0Obiamaka Obianyo1Elfriede Dall2Yuhong Du3Haian Fu4Xia Liu5Seong Su Kang6Mingke Song7Shan-Ping Yu8Chiara Cabrele9Mario Schubert10Xiaoguang Li11Jian-Zhi Wang12Hans Brandstetter13Keqiang Ye14Department of Pathology and Laboratory Medicine, Emory University School of MedicineDepartment of Pathology and Laboratory Medicine, Emory University School of MedicineDepartment of Molecular Biology, University of SalzburgDepartment of Pharmacology, Emory Chemical Biology Discovery Center, Emory University School of MedicineDepartment of Pharmacology, Emory Chemical Biology Discovery Center, Emory University School of MedicineDepartment of Pathology and Laboratory Medicine, Emory University School of MedicineDepartment of Pathology and Laboratory Medicine, Emory University School of MedicineDepartment of Anesthesiology Emory University School of MedicineDepartment of Anesthesiology Emory University School of MedicineDepartment of Molecular Biology, University of SalzburgDepartment of Molecular Biology, University of SalzburgPathophysiology Department, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and TechnologyPathophysiology Department, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Molecular Biology, University of SalzburgDepartment of Pathology and Laboratory Medicine, Emory University School of MedicineDelta-secretases are associated with Alzheimer’s disease (AD) as they cleave both amyloid precursor protein and tau. Here the authors develop a series of orally bioactive small molecule delta-secretase inhibitors and report its therapeutic effects in mouse models of AD.https://doi.org/10.1038/ncomms14740 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Zhentao Zhang Obiamaka Obianyo Elfriede Dall Yuhong Du Haian Fu Xia Liu Seong Su Kang Mingke Song Shan-Ping Yu Chiara Cabrele Mario Schubert Xiaoguang Li Jian-Zhi Wang Hans Brandstetter Keqiang Ye |
| spellingShingle |
Zhentao Zhang Obiamaka Obianyo Elfriede Dall Yuhong Du Haian Fu Xia Liu Seong Su Kang Mingke Song Shan-Ping Yu Chiara Cabrele Mario Schubert Xiaoguang Li Jian-Zhi Wang Hans Brandstetter Keqiang Ye Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease Nature Communications |
| author_facet |
Zhentao Zhang Obiamaka Obianyo Elfriede Dall Yuhong Du Haian Fu Xia Liu Seong Su Kang Mingke Song Shan-Ping Yu Chiara Cabrele Mario Schubert Xiaoguang Li Jian-Zhi Wang Hans Brandstetter Keqiang Ye |
| author_sort |
Zhentao Zhang |
| title |
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease |
| title_short |
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease |
| title_full |
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease |
| title_fullStr |
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease |
| title_full_unstemmed |
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease |
| title_sort |
inhibition of delta-secretase improves cognitive functions in mouse models of alzheimer’s disease |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-03-01 |
| description |
Delta-secretases are associated with Alzheimer’s disease (AD) as they cleave both amyloid precursor protein and tau. Here the authors develop a series of orally bioactive small molecule delta-secretase inhibitors and report its therapeutic effects in mouse models of AD. |
| url |
https://doi.org/10.1038/ncomms14740 |
| work_keys_str_mv |
AT zhentaozhang inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT obiamakaobianyo inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT elfriededall inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT yuhongdu inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT haianfu inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT xialiu inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT seongsukang inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT mingkesong inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT shanpingyu inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT chiaracabrele inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT marioschubert inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT xiaoguangli inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT jianzhiwang inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT hansbrandstetter inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT keqiangye inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease |
| _version_ |
1721451921227644928 |