mTORC1 signaling in hepatic lipid metabolism

mTORC1 signaling in hepatic lipid metabolism

ABSTRACT The mechanistic target of rapamycin (mTOR) signaling pathway regulates many metabolic and physiological processes in different organs or tissues. Dysregulation of mTOR signaling has been implicated in many human diseases including obesity, diabetes, cancer, fatty liver diseases, and neurona...

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Bibliographic Details
Main Authors: Jinbo Han, Yiguo Wang
Format: Article
Language:English
Published: SpringerOpen 2017-04-01
Series:Protein & Cell
Subjects:
mTOR
mTORC1
lipogenesis
lipophagy
Online Access:http://link.springer.com/article/10.1007/s13238-017-0409-3
Description
Summary:ABSTRACT The mechanistic target of rapamycin (mTOR) signaling pathway regulates many metabolic and physiological processes in different organs or tissues. Dysregulation of mTOR signaling has been implicated in many human diseases including obesity, diabetes, cancer, fatty liver diseases, and neuronal disorders. Here we review recent progress in understanding how mTORC1 (mTOR complex 1) signaling regulates lipid metabolism in the liver.
ISSN:1674-800X
1674-8018

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