Inkjet printed drug-releasing polyelectrolyte multilayers for wound dressings

• Main Authors: Huilin Yang, Amy M. Peterson
• Format: Article
• Language: English
• Published: AIMS Press 2017-03-01
• Series: AIMS Materials Science
• Subjects: polyelectrolyte multilayers; polyelectrolyte complexes; inkjet printing; Escheria coli; gentamicin; surface properties
• Online Access: http://www.aimspress.com/Materials/article/1312/fulltext.html

Inkjet printing was used as a novel processing method for the preparation of polyelectrolyte multilayers. Conformal, consistent coatings were formed on a cotton substrate. As a demonstration of a potential application of this processing method, polyelectrolyte multilayers were assembled on cotton for wound dressing. When loaded with gentamicin, these coatings demonstrated burst release of 50% of the loaded gentamicin over the first five hours, followed by consistent release of 0.15 µg/(cm²-h) for at least four days. Significant antimicrobial activity of the gentamicin-releasing polyelectrolyte multilayer-coated cotton was observed, with a zone of inhibition of 1.575 ± 0.03 cm. This result is comparable to the zone of inhibition for cotton soaked in gentamicin (1.75 ± 0.04 cm), indicating that the inkjet printing processing method does not degrade gentamicin. Inkjet printing shows promise as a low cost, versatile option for polyelectrolyte multilayer fabrication. Additionally, as a scalable process, inkjet printed samples exhibited consistent antibacterial function for over three months after preparation.