Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and Ipilimumab
Treatment options for patients with platinum-refractory, recurrent, metastatic head and neck squamous cell carcinoma (HNSCC) are limited, and prognosis is poor. Nivolumab (Opdivo) has been approved by the US Food and Drug Administration (FDA) for the treatment of patients with recurrent or metastati...
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doaj-af56c7c0dae948ba8dee48309c4f11322020-11-24T23:04:20ZengKarger PublishersCase Reports in Oncology1662-65752018-01-01111172010.1159/000485562485562Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and IpilimumabKatjana S. SchwabGlenn KristiansenHans H. SchildStefanie E.A. HeldAnnkristin HeinePeter BrossartTreatment options for patients with platinum-refractory, recurrent, metastatic head and neck squamous cell carcinoma (HNSCC) are limited, and prognosis is poor. Nivolumab (Opdivo) has been approved by the US Food and Drug Administration (FDA) for the treatment of patients with recurrent or metastatic HNSCC who have disease progression on or after platinum-based therapy. Recently, in patients with metastatic malignant melanoma a significant improvement of outcome and response was achieved with the combination of ipilimumab (CTLA4 antibody) and the programmed death (PD)-1 inhibitor nivolumab compared with monotherapy. Based on these results, the combination of nivolumab and ipilimumab has been approved by the FDA for the treatment of patients with unresectable or metastatic melanoma. So far, there have been no data concerning the combination of nivolumab and ipilimumab in squamous cell head and neck cancer. We here present the case of a 46-year-old male with refractory squamous cell head and neck cancer, who was successfully treated with the PD-1 inhibitor nivolumab in combination with the anti-CTLA4 antibody ipilimumab.https://www.karger.com/Article/FullText/485562NivolumabIpilimumabSquamous cell carcinomaAnti-PD-1 inhibitorAnti-CTLA4 antibodyAnti-programmed cell death protein 1 inhibitor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katjana S. Schwab Glenn Kristiansen Hans H. Schild Stefanie E.A. Held Annkristin Heine Peter Brossart |
spellingShingle |
Katjana S. Schwab Glenn Kristiansen Hans H. Schild Stefanie E.A. Held Annkristin Heine Peter Brossart Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and Ipilimumab Case Reports in Oncology Nivolumab Ipilimumab Squamous cell carcinoma Anti-PD-1 inhibitor Anti-CTLA4 antibody Anti-programmed cell death protein 1 inhibitor |
author_facet |
Katjana S. Schwab Glenn Kristiansen Hans H. Schild Stefanie E.A. Held Annkristin Heine Peter Brossart |
author_sort |
Katjana S. Schwab |
title |
Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and Ipilimumab |
title_short |
Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and Ipilimumab |
title_full |
Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and Ipilimumab |
title_fullStr |
Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and Ipilimumab |
title_full_unstemmed |
Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and Ipilimumab |
title_sort |
successful treatment of refractory squamous cell cancer of the head and neck with nivolumab and ipilimumab |
publisher |
Karger Publishers |
series |
Case Reports in Oncology |
issn |
1662-6575 |
publishDate |
2018-01-01 |
description |
Treatment options for patients with platinum-refractory, recurrent, metastatic head and neck squamous cell carcinoma (HNSCC) are limited, and prognosis is poor. Nivolumab (Opdivo) has been approved by the US Food and Drug Administration (FDA) for the treatment of patients with recurrent or metastatic HNSCC who have disease progression on or after platinum-based therapy. Recently, in patients with metastatic malignant melanoma a significant improvement of outcome and response was achieved with the combination of ipilimumab (CTLA4 antibody) and the programmed death (PD)-1 inhibitor nivolumab compared with monotherapy. Based on these results, the combination of nivolumab and ipilimumab has been approved by the FDA for the treatment of patients with unresectable or metastatic melanoma. So far, there have been no data concerning the combination of nivolumab and ipilimumab in squamous cell head and neck cancer. We here present the case of a 46-year-old male with refractory squamous cell head and neck cancer, who was successfully treated with the PD-1 inhibitor nivolumab in combination with the anti-CTLA4 antibody ipilimumab. |
topic |
Nivolumab Ipilimumab Squamous cell carcinoma Anti-PD-1 inhibitor Anti-CTLA4 antibody Anti-programmed cell death protein 1 inhibitor |
url |
https://www.karger.com/Article/FullText/485562 |
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