The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity

• Main Authors: Daniela Maria Tanase, Evelina Maria Gosav, Smaranda Radu, Claudia Florida Costea, Manuela Ciocoiu, Alexandru Carauleanu, Cristina Mihaela Lacatusu, Minela Aida Maranduca, Mariana Floria, Ciprian Rezus
• Format: Article
• Language: English
• Published: MDPI AG 2019-10-01
• Series: International Journal of Molecular Sciences
• Subjects: kidney injury molecule-1; acute kidney injury; cisplatin nephrotoxicity
• Online Access: https://www.mdpi.com/1422-0067/20/20/5238

Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently reported serious side-effect. However, there are no approved biomarkers that can properly identify proximal tubular injury while routine assessments such as serum creatinine lack sensitivity. Kidney-injury-molecule 1 (KIM-1) is showing promise in identifying cisplatin-induced renal injury both in vitro and in vivo studies. In this review, we focus on describing the mechanisms of renal tubular cells cisplatin-induced apoptosis, the associated inflammatory response and oxidative stress and the role of KIM-1 as a possible biomarker used to predict cisplatin associated AKI.