Clinical Application and Evaluation of Pharmacogenomics in Tumor Chemotherapy

• Main Author: Jifeng Feng
• Format: Article
• Language: English
• Published: Third Party Medicine International Publishing Group Co. Limited 2014-03-01
• Series: Journal of International Translational Medicine
• Subjects: Pharmacogenomics; Pharmacogenetics; Chemotherapy regimen; Individualized treatment
• Online Access: http://www.jitm.hk/EN/abstract/abstract42.shtml

In the treatment of tumor patients, how to select the chemotherapy regimen with better efficacy, less toxicity and expense is a difficult problem that perplexes clinical doctors for a long time. Pharmacogenetics is to study the influence of genetic factors on pharmacokinetics, whereas pharmacogenomics is to study the relationship between various gene mutations and drug efficacy and safety. With molecular biology developing, pharmacogenetics and pharmacogenomics are considered to be essential in the reduction of adverse reactions, improvement of efficacy and realization of individualized treatment. In this article, the clinical application and evaluation of pharmacogenomics in tumor chemotherapy were primarily investigated.