Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia solium
Human neurocysticercosis by Taenia solium is considered an emergent severe brain disorder in developing and developed countries. Discovery of new antiparasitic drugs has been recently aimed to restrain differentiation and establishment of the T. solium adult tapeworm, for being considered a central...
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Online Access: | http://dx.doi.org/10.1155/2013/280496 |
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doaj-af5ccf3378d54e0380d9b0406af0ab272020-11-25T00:11:58ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/280496280496Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia soliumGalileo Escobedo0M. Isabel Palacios-Arreola1Alfonso Olivos2Lorena López-Griego3Jorge Morales-Montor4Unidad de Medicina Experimental, Hospital General de México, México, DF 06726, MexicoDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, México, DF 04510, MexicoDepartamento de Medicina Experimental, Hospital General de México, Facultad de Medicina, Universidad Nacional Autónoma de México, México, DF 06726, MexicoDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, México, DF 04510, MexicoDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, México, DF 04510, MexicoHuman neurocysticercosis by Taenia solium is considered an emergent severe brain disorder in developing and developed countries. Discovery of new antiparasitic drugs has been recently aimed to restrain differentiation and establishment of the T. solium adult tapeworm, for being considered a central node in the disease propagation to both pigs and humans. Tamoxifen is an antiestrogenic drug with cysticidal action on Taenia crassiceps, a close relative of T. solium. Thus, we evaluated the effect of tamoxifen on the in vitro evagination and the in vivo establishment of T. solium. In vitro, tamoxifen inhibited evagination of T. solium cysticerci in a dose-time dependent manner. In vivo, administration of tamoxifen to hamsters decreased the intestinal establishment of the parasite by 70%, while recovered tapeworms showed an 80% reduction in length, appearing as scolices without strobilar development. Since tamoxifen did not show any significant effect on the proliferation of antigen-specific immune cells, intestinal inflammation, and expression of Th1/Th2 cytokines in spleen and duodenum, this drug could exert its antiparasite actions by having direct detrimental effects upon the adult tapeworm. These results demonstrate that tamoxifen exhibits a strong cysticidal and antitaeniasic effect on T. solium that should be further explored in humans and livestock.http://dx.doi.org/10.1155/2013/280496 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Galileo Escobedo M. Isabel Palacios-Arreola Alfonso Olivos Lorena López-Griego Jorge Morales-Montor |
spellingShingle |
Galileo Escobedo M. Isabel Palacios-Arreola Alfonso Olivos Lorena López-Griego Jorge Morales-Montor Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia solium BioMed Research International |
author_facet |
Galileo Escobedo M. Isabel Palacios-Arreola Alfonso Olivos Lorena López-Griego Jorge Morales-Montor |
author_sort |
Galileo Escobedo |
title |
Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia solium |
title_short |
Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia solium |
title_full |
Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia solium |
title_fullStr |
Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia solium |
title_full_unstemmed |
Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia solium |
title_sort |
tamoxifen treatment in hamsters induces protection during taeniosis by taenia solium |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2013-01-01 |
description |
Human neurocysticercosis by Taenia solium is considered an emergent severe brain disorder in developing and developed countries. Discovery of new antiparasitic drugs has been recently aimed to restrain differentiation and establishment of the T. solium adult tapeworm, for being considered a central node in the disease propagation to both pigs and humans. Tamoxifen is an antiestrogenic drug with cysticidal action on Taenia crassiceps, a close relative of T. solium. Thus, we evaluated the effect of tamoxifen on the in vitro evagination and the in vivo establishment of T. solium. In vitro, tamoxifen inhibited evagination of T. solium cysticerci in a dose-time dependent manner. In vivo, administration of tamoxifen to hamsters decreased the intestinal establishment of the parasite by 70%, while recovered tapeworms showed an 80% reduction in length, appearing as scolices without strobilar development. Since tamoxifen did not show any significant effect on the proliferation of antigen-specific immune cells, intestinal inflammation, and expression of Th1/Th2 cytokines in spleen and duodenum, this drug could exert its antiparasite actions by having direct detrimental effects upon the adult tapeworm. These results demonstrate that tamoxifen exhibits a strong cysticidal and antitaeniasic effect on T. solium that should be further explored in humans and livestock. |
url |
http://dx.doi.org/10.1155/2013/280496 |
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