Doxepin for radiation therapy-induced mucositis pain in the treatment of oral cancers
Radiotherapy (RT), an integral part of the oncologic treatment for patients with head and neck cancer, can cause adverse side effects such as oral mucositis (OM). Pain from OM can impact a patient’s quality of life and interrupt RT treatment schedules, which decreases the probability for achieving c...
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doaj-af5facc26949409c96ee637c097266242020-11-25T02:59:46ZengPAGEPress PublicationsOncology Reviews1970-55571970-55652015-12-019110.4081/oncol.2015.290208Doxepin for radiation therapy-induced mucositis pain in the treatment of oral cancersRitujith Jayakrishnan0Kenneth Chang1Gamze Ugurluer2Robert C. Miller3Terence T. Sio4Department of Radiation Oncology, Mayo Clinic, Rochester, MNDepartment of Radiation Oncology, Mayo Clinic, Rochester, MNDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN, USA; Department of Radiation Oncology, Acibadem Adana Hospital, Acibadem University, AdanaDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FLDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN; Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZRadiotherapy (RT), an integral part of the oncologic treatment for patients with head and neck cancer, can cause adverse side effects such as oral mucositis (OM). Pain from OM can impact a patient’s quality of life and interrupt RT treatment schedules, which decreases the probability for achieving cancer cure. Conventionally, RT-induced OM pain is treated with analgesics and/or mouthwash rinses. Doxepin, a traditional tricyclic antidepressant with analgesic and anesthetic properties when applied topically to the mucosa, has been shown to lower OM pain in multiple single-arm trials (Epstein et al.) and more recently, in a placebo-controlled crossover study (Leenstra and Miller et al.). Currently, a placebo-controlled study (Sio and Miller et al.) using doxepin for esophagitis pain caused by RT to the thorax is underway. Doxepin will also be further compared with magic mouthwash and a placebo solution in a three-arm trial (Miller and Sio et al.) with head and neck cancer patients with OM pain caused by RT. Doxepin may represent a new standard for treating RT-induced OM pain in the future.http://www.oncologyreviews.org/index.php/or/article/view/290Oral mucositisradiation therapydoxepinhead and neck cancersymptom control. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ritujith Jayakrishnan Kenneth Chang Gamze Ugurluer Robert C. Miller Terence T. Sio |
spellingShingle |
Ritujith Jayakrishnan Kenneth Chang Gamze Ugurluer Robert C. Miller Terence T. Sio Doxepin for radiation therapy-induced mucositis pain in the treatment of oral cancers Oncology Reviews Oral mucositis radiation therapy doxepin head and neck cancer symptom control. |
author_facet |
Ritujith Jayakrishnan Kenneth Chang Gamze Ugurluer Robert C. Miller Terence T. Sio |
author_sort |
Ritujith Jayakrishnan |
title |
Doxepin for radiation therapy-induced mucositis pain in the treatment of oral cancers |
title_short |
Doxepin for radiation therapy-induced mucositis pain in the treatment of oral cancers |
title_full |
Doxepin for radiation therapy-induced mucositis pain in the treatment of oral cancers |
title_fullStr |
Doxepin for radiation therapy-induced mucositis pain in the treatment of oral cancers |
title_full_unstemmed |
Doxepin for radiation therapy-induced mucositis pain in the treatment of oral cancers |
title_sort |
doxepin for radiation therapy-induced mucositis pain in the treatment of oral cancers |
publisher |
PAGEPress Publications |
series |
Oncology Reviews |
issn |
1970-5557 1970-5565 |
publishDate |
2015-12-01 |
description |
Radiotherapy (RT), an integral part of the oncologic treatment for patients with head and neck cancer, can cause adverse side effects such as oral mucositis (OM). Pain from OM can impact a patient’s quality of life and interrupt RT treatment schedules, which decreases the probability for achieving cancer cure. Conventionally, RT-induced OM pain is treated with analgesics and/or mouthwash rinses. Doxepin, a traditional tricyclic antidepressant with analgesic and anesthetic properties when applied topically to the mucosa, has been shown to lower OM pain in multiple single-arm trials (Epstein et al.) and more recently, in a placebo-controlled crossover study (Leenstra and Miller et al.). Currently, a placebo-controlled study (Sio and Miller et al.) using doxepin for esophagitis pain caused by RT to the thorax is underway. Doxepin will also be further compared with magic mouthwash and a placebo solution in a three-arm trial (Miller and Sio et al.) with head and neck cancer patients with OM pain caused by RT. Doxepin may represent a new standard for treating RT-induced OM pain in the future. |
topic |
Oral mucositis radiation therapy doxepin head and neck cancer symptom control. |
url |
http://www.oncologyreviews.org/index.php/or/article/view/290 |
work_keys_str_mv |
AT ritujithjayakrishnan doxepinforradiationtherapyinducedmucositispaininthetreatmentoforalcancers AT kennethchang doxepinforradiationtherapyinducedmucositispaininthetreatmentoforalcancers AT gamzeugurluer doxepinforradiationtherapyinducedmucositispaininthetreatmentoforalcancers AT robertcmiller doxepinforradiationtherapyinducedmucositispaininthetreatmentoforalcancers AT terencetsio doxepinforradiationtherapyinducedmucositispaininthetreatmentoforalcancers |
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