Low frequency of circulating CD8+ T stem cell memory cells in chronic chagasic patients with severe forms of the disease.
CD8+ T cells have been shown to play a crucial role in Trypanosoma cruzi infection. Memory CD8+ T cells can be categorised based on their distinct differentiation stages and functional activities as follows: stem cell memory (TSCM), central memory (TCM), transitional memory (TTM), effector memory (T...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS Neglected Tropical Diseases |
Online Access: | http://europepmc.org/articles/PMC4287481?pdf=render |
id |
doaj-af5fd531b62d409abddd6bedfd758adf |
---|---|
record_format |
Article |
spelling |
doaj-af5fd531b62d409abddd6bedfd758adf2020-11-25T01:55:03ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352015-01-0191e343210.1371/journal.pntd.0003432Low frequency of circulating CD8+ T stem cell memory cells in chronic chagasic patients with severe forms of the disease.Jose MateusPaola LassoPaula PaviaFernando RosasNubia RoaCarlos Andrés Valencia-HernándezJohn Mario GonzálezConcepción J PuertaAdriana CuéllarCD8+ T cells have been shown to play a crucial role in Trypanosoma cruzi infection. Memory CD8+ T cells can be categorised based on their distinct differentiation stages and functional activities as follows: stem cell memory (TSCM), central memory (TCM), transitional memory (TTM), effector memory (TEM) and terminal effector (TTE) cells. Currently, the immune mechanisms that control T. cruzi in the chronic phase of the infection are unknown.To characterise the CD8+ T cell subsets that could be participating in the control of T. cruzi infection, in this study, we compared total and T. cruzi-specific circulating CD8+ T cells with distinctive phenotypic and functional features in chronic chagasic patients (CCPs) with different degrees of cardiac dysfunction. We observed a decreased frequency of total TSCM along with an increased frequency of TTE in CCPs with severe disease. Antigen-specific TSCM cells were not detectable in CCPs with severe forms of the disease. A functional profile of CD8+ T cell subsets among CCPs revealed a high frequency of monofunctional CD8+ T cells in the most severe patients with IFN-γ+- or TNF-α+-producing cells.These findings suggest that CD8+ TSCM cells may be associated with the immune response to T. cruzi and outcome of Chagas disease, given that these cells may be involved in repopulating the T cell pool that controls infection.http://europepmc.org/articles/PMC4287481?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jose Mateus Paola Lasso Paula Pavia Fernando Rosas Nubia Roa Carlos Andrés Valencia-Hernández John Mario González Concepción J Puerta Adriana Cuéllar |
spellingShingle |
Jose Mateus Paola Lasso Paula Pavia Fernando Rosas Nubia Roa Carlos Andrés Valencia-Hernández John Mario González Concepción J Puerta Adriana Cuéllar Low frequency of circulating CD8+ T stem cell memory cells in chronic chagasic patients with severe forms of the disease. PLoS Neglected Tropical Diseases |
author_facet |
Jose Mateus Paola Lasso Paula Pavia Fernando Rosas Nubia Roa Carlos Andrés Valencia-Hernández John Mario González Concepción J Puerta Adriana Cuéllar |
author_sort |
Jose Mateus |
title |
Low frequency of circulating CD8+ T stem cell memory cells in chronic chagasic patients with severe forms of the disease. |
title_short |
Low frequency of circulating CD8+ T stem cell memory cells in chronic chagasic patients with severe forms of the disease. |
title_full |
Low frequency of circulating CD8+ T stem cell memory cells in chronic chagasic patients with severe forms of the disease. |
title_fullStr |
Low frequency of circulating CD8+ T stem cell memory cells in chronic chagasic patients with severe forms of the disease. |
title_full_unstemmed |
Low frequency of circulating CD8+ T stem cell memory cells in chronic chagasic patients with severe forms of the disease. |
title_sort |
low frequency of circulating cd8+ t stem cell memory cells in chronic chagasic patients with severe forms of the disease. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Neglected Tropical Diseases |
issn |
1935-2727 1935-2735 |
publishDate |
2015-01-01 |
description |
CD8+ T cells have been shown to play a crucial role in Trypanosoma cruzi infection. Memory CD8+ T cells can be categorised based on their distinct differentiation stages and functional activities as follows: stem cell memory (TSCM), central memory (TCM), transitional memory (TTM), effector memory (TEM) and terminal effector (TTE) cells. Currently, the immune mechanisms that control T. cruzi in the chronic phase of the infection are unknown.To characterise the CD8+ T cell subsets that could be participating in the control of T. cruzi infection, in this study, we compared total and T. cruzi-specific circulating CD8+ T cells with distinctive phenotypic and functional features in chronic chagasic patients (CCPs) with different degrees of cardiac dysfunction. We observed a decreased frequency of total TSCM along with an increased frequency of TTE in CCPs with severe disease. Antigen-specific TSCM cells were not detectable in CCPs with severe forms of the disease. A functional profile of CD8+ T cell subsets among CCPs revealed a high frequency of monofunctional CD8+ T cells in the most severe patients with IFN-γ+- or TNF-α+-producing cells.These findings suggest that CD8+ TSCM cells may be associated with the immune response to T. cruzi and outcome of Chagas disease, given that these cells may be involved in repopulating the T cell pool that controls infection. |
url |
http://europepmc.org/articles/PMC4287481?pdf=render |
work_keys_str_mv |
AT josemateus lowfrequencyofcirculatingcd8tstemcellmemorycellsinchronicchagasicpatientswithsevereformsofthedisease AT paolalasso lowfrequencyofcirculatingcd8tstemcellmemorycellsinchronicchagasicpatientswithsevereformsofthedisease AT paulapavia lowfrequencyofcirculatingcd8tstemcellmemorycellsinchronicchagasicpatientswithsevereformsofthedisease AT fernandorosas lowfrequencyofcirculatingcd8tstemcellmemorycellsinchronicchagasicpatientswithsevereformsofthedisease AT nubiaroa lowfrequencyofcirculatingcd8tstemcellmemorycellsinchronicchagasicpatientswithsevereformsofthedisease AT carlosandresvalenciahernandez lowfrequencyofcirculatingcd8tstemcellmemorycellsinchronicchagasicpatientswithsevereformsofthedisease AT johnmariogonzalez lowfrequencyofcirculatingcd8tstemcellmemorycellsinchronicchagasicpatientswithsevereformsofthedisease AT concepcionjpuerta lowfrequencyofcirculatingcd8tstemcellmemorycellsinchronicchagasicpatientswithsevereformsofthedisease AT adrianacuellar lowfrequencyofcirculatingcd8tstemcellmemorycellsinchronicchagasicpatientswithsevereformsofthedisease |
_version_ |
1724985367886561280 |