SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL

Hepatitis C virus (HCV) causes a severe liver disease frequentlyassociatedwith cirrhosis andhepatocellular carcinoma. No effective anti-HCVtherapyis available so far. Thus, it is pertinent to applymathematical modelingto prediction ofthe efficiencyofnew candidate pharmaceuticals. Astochastic mathema...

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Main Authors:	E. L. Mishchenko, N. V. Ivanisenko, I. R. Akberdin, P. S. Demenkov, V. A. Likhoshvai, N. A. Kolchanov, V. A. Ivanisenko
Format:	Article
Language:	English
Published:	Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences 2014-12-01
Series:	Vavilovskij Žurnal Genetiki i Selekcii
Subjects:	hepatitis c virus subgenomic replicon mathematical modeling effectiveness of drugs
Online Access:	https://vavilov.elpub.ru/jour/article/view/50

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spelling	doaj-af6ec3b20bcc40a291d8efa485a1dd5c2021-09-11T08:41:13ZengInstitute of Cytology and Genetics of Siberian Branch of the Russian Academy of SciencesVavilovskij Žurnal Genetiki i Selekcii2500-04622500-32592014-12-0116233934734SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODELE. L. Mishchenko0N. V. Ivanisenko1I. R. Akberdin2P. S. Demenkov3V. A. Likhoshvai4N. A. Kolchanov5V. A. Ivanisenko6Institute of Cytology and Genetics, SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics, SB RAS, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, RussiaInstitute of Cytology and Genetics, SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics, SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics, SB RAS, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, RussiaInstitute of Cytology and Genetics, SB RAS, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, RussiaInstitute of Cytology and Genetics, SB RAS, Novosibirsk, RussiaHepatitis C virus (HCV) causes a severe liver disease frequentlyassociatedwith cirrhosis andhepatocellular carcinoma. No effective anti-HCVtherapyis available so far. Thus, it is pertinent to applymathematical modelingto prediction ofthe efficiencyofnew candidate pharmaceuticals. Astochastic mathematical model for subgenomic HCVreplicon replication in Huh-7 cells with the presence ofthe HCVNS3 protease inhibitor SCH 503034 is proposed. The model describes the experimental kinetic curves ofviral RNAsuppression at various SCH 503034 concentrations. It is applicable to the development ofapproaches to HCVRNAsuppression in Huh-7 cells.https://vavilov.elpub.ru/jour/article/view/50hepatitis c virussubgenomic repliconmathematical modelingeffectiveness of drugs
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	E. L. Mishchenko N. V. Ivanisenko I. R. Akberdin P. S. Demenkov V. A. Likhoshvai N. A. Kolchanov V. A. Ivanisenko
spellingShingle	E. L. Mishchenko N. V. Ivanisenko I. R. Akberdin P. S. Demenkov V. A. Likhoshvai N. A. Kolchanov V. A. Ivanisenko SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL Vavilovskij Žurnal Genetiki i Selekcii hepatitis c virus subgenomic replicon mathematical modeling effectiveness of drugs
author_facet	E. L. Mishchenko N. V. Ivanisenko I. R. Akberdin P. S. Demenkov V. A. Likhoshvai N. A. Kolchanov V. A. Ivanisenko
author_sort	E. L. Mishchenko
title	SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL
title_short	SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL
title_full	SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL
title_fullStr	SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL
title_full_unstemmed	SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL
title_sort	suppression of subgenomic hepatitis c virus rna replicon replication in huh-7 cells by the ns3 protease inhibitor sch5030334: a stochastic mathematical model
publisher	Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences
series	Vavilovskij Žurnal Genetiki i Selekcii
issn	2500-0462 2500-3259
publishDate	2014-12-01
description	Hepatitis C virus (HCV) causes a severe liver disease frequentlyassociatedwith cirrhosis andhepatocellular carcinoma. No effective anti-HCVtherapyis available so far. Thus, it is pertinent to applymathematical modelingto prediction ofthe efficiencyofnew candidate pharmaceuticals. Astochastic mathematical model for subgenomic HCVreplicon replication in Huh-7 cells with the presence ofthe HCVNS3 protease inhibitor SCH 503034 is proposed. The model describes the experimental kinetic curves ofviral RNAsuppression at various SCH 503034 concentrations. It is applicable to the development ofapproaches to HCVRNAsuppression in Huh-7 cells.
topic	hepatitis c virus subgenomic replicon mathematical modeling effectiveness of drugs
url	https://vavilov.elpub.ru/jour/article/view/50
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SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL

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