Inhibition of Sonic Hedgehog Signaling Suppresses Glioma Stem-Like Cells Likely Through Inducing Autophagic Cell Death

Inhibition of Sonic Hedgehog Signaling Suppresses Glioma Stem-Like Cells Likely Through Inducing Autophagic Cell Death

Glioblastoma (GBM) often recurs after radio- and chemotherapies leading to poor prognosis. Glioma stem-like cells (GSCs) contribute to drug resistance and recurrence. Thus, understanding cellular mechanism underlying the growth of GSCs is critical for the treatment of GBM. Here GSCs were isolated fr...

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Bibliographic Details
Main Authors: Hui-Chi Hung, Chan-Chuan Liu, Jian-Ying Chuang, Chun-Lin Su, Po-Wu Gean
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
sonic hedgehog
glioblastoma
stem-like cells
autophagy
amiodarone
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01233/full

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