Mid-pregnancy maternal immune activation increases Pax6-positive and Tbr2-positive neural progenitor cells and causes integrated stress response in the fetal brain in a mouse model of maternal viral infection
Maternal immune activation (MIA) in midpregnancy is a risk factor for neurodevelopmental disorders. Improper brain development may cause malformations of the brain; maldevelopment induced by MIA may lead to a pathology-related phenotype. In this study, a single intraperitoneal injection of 20 mg/kg...
Main Authors: | Tsuyoshi Tsukada, Hiromi Sakata-Haga, Hiroki Shimada, Hiroki Shoji, Toshihisa Hatta |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-12-01
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Series: | IBRO Neuroscience Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242121000312 |
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