Specific Immune Response and Cytokine Production in CD70 Deficiency
Collective clinical and immunologic findings of defects in the CD27–CD70 axis indicate a primary immunodeficiency associated with terminal B-cell development defect and immune dysregulation leading to autoimmunity, uncontrolled viral infection, and lymphoma. Since the molecular mechanism underlying...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-04-01
|
Series: | Frontiers in Pediatrics |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2021.615724/full |
id |
doaj-af7d04f983824ce882f9f1728143b6d6 |
---|---|
record_format |
Article |
spelling |
doaj-af7d04f983824ce882f9f1728143b6d62021-04-30T06:47:16ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602021-04-01910.3389/fped.2021.615724615724Specific Immune Response and Cytokine Production in CD70 DeficiencyHassan Abolhassani0Hassan Abolhassani1Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, SwedenResearch Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, IranCollective clinical and immunologic findings of defects in the CD27–CD70 axis indicate a primary immunodeficiency associated with terminal B-cell development defect and immune dysregulation leading to autoimmunity, uncontrolled viral infection, and lymphoma. Since the molecular mechanism underlying this entity of primary immunodeficiency has been recently described, more insight regarding the function and profile of immunity is required. Therefore, this study aimed to investigate stimulated antibody production, polyclonal vs. virus-specific T-cell response, and cytokine production of a CD70-deficient patient reported previously with early-onset antibody deficiency suffering from chronic viral infections and B-cell lymphoma. The patient and her family members were subjected to clinical evaluation, immunological assays, and functional analyses. The findings of this study indicate an impaired ability of B cells to produce immunoglobulins, and a poor effector function of T cells was also associated with the severity of clinical phenotype. Reduced proportions of cells expressing the memory marker CD45RO, as well as T-bet and Eomes, were observed in CD70-deficient T cells. The proportion of 2B4+ and PD-1+ virus-specific CD8+ T cells was also reduced in the patient. Although the CD70-mutated individuals presented with early-onset clinical manifestations that were well-controlled by using conventional immunological and anticancer chemotherapies, with better prognosis as compared with CD27-deficient patients, targeted treatment toward specific disturbed immune profile may improve the management and even prevent secondary complications.https://www.frontiersin.org/articles/10.3389/fped.2021.615724/fullprimary immunodeficiencyinborn errors of immunityCD70 deficiencyclass-switching recombinationT-betEomes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hassan Abolhassani Hassan Abolhassani |
spellingShingle |
Hassan Abolhassani Hassan Abolhassani Specific Immune Response and Cytokine Production in CD70 Deficiency Frontiers in Pediatrics primary immunodeficiency inborn errors of immunity CD70 deficiency class-switching recombination T-bet Eomes |
author_facet |
Hassan Abolhassani Hassan Abolhassani |
author_sort |
Hassan Abolhassani |
title |
Specific Immune Response and Cytokine Production in CD70 Deficiency |
title_short |
Specific Immune Response and Cytokine Production in CD70 Deficiency |
title_full |
Specific Immune Response and Cytokine Production in CD70 Deficiency |
title_fullStr |
Specific Immune Response and Cytokine Production in CD70 Deficiency |
title_full_unstemmed |
Specific Immune Response and Cytokine Production in CD70 Deficiency |
title_sort |
specific immune response and cytokine production in cd70 deficiency |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pediatrics |
issn |
2296-2360 |
publishDate |
2021-04-01 |
description |
Collective clinical and immunologic findings of defects in the CD27–CD70 axis indicate a primary immunodeficiency associated with terminal B-cell development defect and immune dysregulation leading to autoimmunity, uncontrolled viral infection, and lymphoma. Since the molecular mechanism underlying this entity of primary immunodeficiency has been recently described, more insight regarding the function and profile of immunity is required. Therefore, this study aimed to investigate stimulated antibody production, polyclonal vs. virus-specific T-cell response, and cytokine production of a CD70-deficient patient reported previously with early-onset antibody deficiency suffering from chronic viral infections and B-cell lymphoma. The patient and her family members were subjected to clinical evaluation, immunological assays, and functional analyses. The findings of this study indicate an impaired ability of B cells to produce immunoglobulins, and a poor effector function of T cells was also associated with the severity of clinical phenotype. Reduced proportions of cells expressing the memory marker CD45RO, as well as T-bet and Eomes, were observed in CD70-deficient T cells. The proportion of 2B4+ and PD-1+ virus-specific CD8+ T cells was also reduced in the patient. Although the CD70-mutated individuals presented with early-onset clinical manifestations that were well-controlled by using conventional immunological and anticancer chemotherapies, with better prognosis as compared with CD27-deficient patients, targeted treatment toward specific disturbed immune profile may improve the management and even prevent secondary complications. |
topic |
primary immunodeficiency inborn errors of immunity CD70 deficiency class-switching recombination T-bet Eomes |
url |
https://www.frontiersin.org/articles/10.3389/fped.2021.615724/full |
work_keys_str_mv |
AT hassanabolhassani specificimmuneresponseandcytokineproductionincd70deficiency AT hassanabolhassani specificimmuneresponseandcytokineproductionincd70deficiency |
_version_ |
1721499781025497088 |