TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

The tumour microenvironment is known to have an acidic pH but how this influences cancer cell phenotype is unclear. Here, the authors show that tumour cells upregulate TGF-β2 under acidosis, which leads to the increased formation of lipid droplets allowing for invasiveness and metastases.

Bibliographic Details
Main Authors: Cyril Corbet, Estelle Bastien, Joao Pedro Santiago de Jesus, Emeline Dierge, Ruben Martherus, Catherine Vander Linden, Bastien Doix, Charline Degavre, Céline Guilbaud, Laurenne Petit, Carine Michiels, Chantal Dessy, Yvan Larondelle, Olivier Feron
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14262-3
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spelling doaj-af7d4d7798c6436891d3d4c7435911322021-05-11T08:16:32ZengNature Publishing GroupNature Communications2041-17232020-01-0111111510.1038/s41467-019-14262-3TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cellsCyril Corbet0Estelle Bastien1Joao Pedro Santiago de Jesus2Emeline Dierge3Ruben Martherus4Catherine Vander Linden5Bastien Doix6Charline Degavre7Céline Guilbaud8Laurenne Petit9Carine Michiels10Chantal Dessy11Yvan Larondelle12Olivier Feron13Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvainPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvainPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvainPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvainPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvainPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvainPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvainPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvainPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvainPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvainLaboratory of Cellular and Molecular Biology (URBC), Namur Research Institute for Life Sciences (NARILIS), University of NamurPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvainLouvain Institute of Biomolecular Science and Technology (LIBST), UCLouvainPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvainThe tumour microenvironment is known to have an acidic pH but how this influences cancer cell phenotype is unclear. Here, the authors show that tumour cells upregulate TGF-β2 under acidosis, which leads to the increased formation of lipid droplets allowing for invasiveness and metastases.https://doi.org/10.1038/s41467-019-14262-3
collection DOAJ
language English
format Article
sources DOAJ
author Cyril Corbet
Estelle Bastien
Joao Pedro Santiago de Jesus
Emeline Dierge
Ruben Martherus
Catherine Vander Linden
Bastien Doix
Charline Degavre
Céline Guilbaud
Laurenne Petit
Carine Michiels
Chantal Dessy
Yvan Larondelle
Olivier Feron
spellingShingle Cyril Corbet
Estelle Bastien
Joao Pedro Santiago de Jesus
Emeline Dierge
Ruben Martherus
Catherine Vander Linden
Bastien Doix
Charline Degavre
Céline Guilbaud
Laurenne Petit
Carine Michiels
Chantal Dessy
Yvan Larondelle
Olivier Feron
TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
Nature Communications
author_facet Cyril Corbet
Estelle Bastien
Joao Pedro Santiago de Jesus
Emeline Dierge
Ruben Martherus
Catherine Vander Linden
Bastien Doix
Charline Degavre
Céline Guilbaud
Laurenne Petit
Carine Michiels
Chantal Dessy
Yvan Larondelle
Olivier Feron
author_sort Cyril Corbet
title TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
title_short TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
title_full TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
title_fullStr TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
title_full_unstemmed TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
title_sort tgfβ2-induced formation of lipid droplets supports acidosis-driven emt and the metastatic spreading of cancer cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-01-01
description The tumour microenvironment is known to have an acidic pH but how this influences cancer cell phenotype is unclear. Here, the authors show that tumour cells upregulate TGF-β2 under acidosis, which leads to the increased formation of lipid droplets allowing for invasiveness and metastases.
url https://doi.org/10.1038/s41467-019-14262-3
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