RING tetramerization is required for nuclear body biogenesis and PML sumoylation

Promyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear body formation and PML sumoylation.

Bibliographic Details
Main Authors:	Pengran Wang, Shirine Benhenda, Haiyan Wu, Valérie Lallemand-Breitenbach, Tao Zhen, Florence Jollivet, Laurent Peres, Yuwen Li, Sai-Juan Chen, Zhu Chen, Hugues de Thé, Guoyu Meng
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03498-0

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spelling	doaj-af84ac66c1354f56901c8f3934d5f6be2021-05-11T09:45:54ZengNature Publishing GroupNature Communications2041-17232018-03-019111010.1038/s41467-018-03498-0RING tetramerization is required for nuclear body biogenesis and PML sumoylationPengran Wang0Shirine Benhenda1Haiyan Wu2Valérie Lallemand-Breitenbach3Tao Zhen4Florence Jollivet5Laurent Peres6Yuwen Li7Sai-Juan Chen8Zhu Chen9Hugues de Thé10Guoyu Meng11State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicineUniversity Paris Diderot, Sorbonne Paris Cité, INSERM U944, CNRS UMR7212, Equipe labellisée LNCCState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicineUniversity Paris Diderot, Sorbonne Paris Cité, INSERM U944, CNRS UMR7212, Equipe labellisée LNCCState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicineUniversity Paris Diderot, Sorbonne Paris Cité, INSERM U944, CNRS UMR7212, Equipe labellisée LNCCUniversity Paris Diderot, Sorbonne Paris Cité, INSERM U944, CNRS UMR7212, Equipe labellisée LNCCState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicineState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicineState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicineUniversity Paris Diderot, Sorbonne Paris Cité, INSERM U944, CNRS UMR7212, Equipe labellisée LNCCState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicinePromyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear body formation and PML sumoylation.https://doi.org/10.1038/s41467-018-03498-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pengran Wang Shirine Benhenda Haiyan Wu Valérie Lallemand-Breitenbach Tao Zhen Florence Jollivet Laurent Peres Yuwen Li Sai-Juan Chen Zhu Chen Hugues de Thé Guoyu Meng
spellingShingle	Pengran Wang Shirine Benhenda Haiyan Wu Valérie Lallemand-Breitenbach Tao Zhen Florence Jollivet Laurent Peres Yuwen Li Sai-Juan Chen Zhu Chen Hugues de Thé Guoyu Meng RING tetramerization is required for nuclear body biogenesis and PML sumoylation Nature Communications
author_facet	Pengran Wang Shirine Benhenda Haiyan Wu Valérie Lallemand-Breitenbach Tao Zhen Florence Jollivet Laurent Peres Yuwen Li Sai-Juan Chen Zhu Chen Hugues de Thé Guoyu Meng
author_sort	Pengran Wang
title	RING tetramerization is required for nuclear body biogenesis and PML sumoylation
title_short	RING tetramerization is required for nuclear body biogenesis and PML sumoylation
title_full	RING tetramerization is required for nuclear body biogenesis and PML sumoylation
title_fullStr	RING tetramerization is required for nuclear body biogenesis and PML sumoylation
title_full_unstemmed	RING tetramerization is required for nuclear body biogenesis and PML sumoylation
title_sort	ring tetramerization is required for nuclear body biogenesis and pml sumoylation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-03-01
description	Promyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear body formation and PML sumoylation.
url	https://doi.org/10.1038/s41467-018-03498-0
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RING tetramerization is required for nuclear body biogenesis and PML sumoylation

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