RING tetramerization is required for nuclear body biogenesis and PML sumoylation
Promyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear body formation and PML sumoylation.
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2018-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-03498-0 |
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doaj-af84ac66c1354f56901c8f3934d5f6be2021-05-11T09:45:54ZengNature Publishing GroupNature Communications2041-17232018-03-019111010.1038/s41467-018-03498-0RING tetramerization is required for nuclear body biogenesis and PML sumoylationPengran Wang0Shirine Benhenda1Haiyan Wu2Valérie Lallemand-Breitenbach3Tao Zhen4Florence Jollivet5Laurent Peres6Yuwen Li7Sai-Juan Chen8Zhu Chen9Hugues de Thé10Guoyu Meng11State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicineUniversity Paris Diderot, Sorbonne Paris Cité, INSERM U944, CNRS UMR7212, Equipe labellisée LNCCState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicineUniversity Paris Diderot, Sorbonne Paris Cité, INSERM U944, CNRS UMR7212, Equipe labellisée LNCCState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicineUniversity Paris Diderot, Sorbonne Paris Cité, INSERM U944, CNRS UMR7212, Equipe labellisée LNCCUniversity Paris Diderot, Sorbonne Paris Cité, INSERM U944, CNRS UMR7212, Equipe labellisée LNCCState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicineState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicineState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicineUniversity Paris Diderot, Sorbonne Paris Cité, INSERM U944, CNRS UMR7212, Equipe labellisée LNCCState Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of MedicinePromyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear body formation and PML sumoylation.https://doi.org/10.1038/s41467-018-03498-0 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pengran Wang Shirine Benhenda Haiyan Wu Valérie Lallemand-Breitenbach Tao Zhen Florence Jollivet Laurent Peres Yuwen Li Sai-Juan Chen Zhu Chen Hugues de Thé Guoyu Meng |
spellingShingle |
Pengran Wang Shirine Benhenda Haiyan Wu Valérie Lallemand-Breitenbach Tao Zhen Florence Jollivet Laurent Peres Yuwen Li Sai-Juan Chen Zhu Chen Hugues de Thé Guoyu Meng RING tetramerization is required for nuclear body biogenesis and PML sumoylation Nature Communications |
author_facet |
Pengran Wang Shirine Benhenda Haiyan Wu Valérie Lallemand-Breitenbach Tao Zhen Florence Jollivet Laurent Peres Yuwen Li Sai-Juan Chen Zhu Chen Hugues de Thé Guoyu Meng |
author_sort |
Pengran Wang |
title |
RING tetramerization is required for nuclear body biogenesis and PML sumoylation |
title_short |
RING tetramerization is required for nuclear body biogenesis and PML sumoylation |
title_full |
RING tetramerization is required for nuclear body biogenesis and PML sumoylation |
title_fullStr |
RING tetramerization is required for nuclear body biogenesis and PML sumoylation |
title_full_unstemmed |
RING tetramerization is required for nuclear body biogenesis and PML sumoylation |
title_sort |
ring tetramerization is required for nuclear body biogenesis and pml sumoylation |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-03-01 |
description |
Promyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear body formation and PML sumoylation. |
url |
https://doi.org/10.1038/s41467-018-03498-0 |
work_keys_str_mv |
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1721449323020943360 |