The Comparison of serum glutathione level between Hypertensive and Normotensive Postmenopausal Women
Background: Blood pressure increases in women after menopause. There is evidences that support the existence of the increased reactive oxygen species levels in hypertension. The glutathione has an important role in cell defense against oxidative stress.The aim of this study was comprising of serum g...
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Hamadan University of Medical Sciences
2017-11-01
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doaj-af855fe911dd4b3faeca047401067cea2020-11-25T03:56:50ZfasHamadan University of Medical Sciences مراقبت پرستاری و مامایی ابن سینا2676-57482676-57482017-11-01254147153The Comparison of serum glutathione level between Hypertensive and Normotensive Postmenopausal WomenMohammad Zarei0Parisa Mohammadi1Pedram Beygvand2Mohammad Amin Fereydouni3Ghodratollah Roshanaei4Mehrdad Hajilooei5Saeed Mohammadi6 Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran Modeling of Noncommunicable Diseases Research Center, Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. Background: Blood pressure increases in women after menopause. There is evidences that support the existence of the increased reactive oxygen species levels in hypertension. The glutathione has an important role in cell defense against oxidative stress.The aim of this study was comprising of serum glutathione level between hypertensive and normotensive postmenopausal women. Methods: This research was a case-control study. The samples were selected among patients who had the inclusion criteria. Samples were 39 postmenopausal women with high blood pressure as case group and the control group was chosen among 40 postmenopausal women with normal blood pressure. After filling in the testimonial and the checklist, blood samples were taken for test subjects. Then the glutathione blood levels were measured using the kit and ELISA. Data were analyzed by t- test, F-test and the non-parametric Mann-Whitney test at a significant level of 5 percent. Results: There was a significant difference between mean systolic and diastolic blood pressure (P= 0.029 & P= 0.047, respectively), serum glutathione level (P= 0.045), body mass index (P= 0.041), and weekly exercise less than 30 minutes (P= 0.049) in postmenopausal women with high blood pressure and normal blood pressure. However, no significant differences in age of onset of menopause, the number of children, employment status, and daily consumption of dairy products was observed between the two groups. Conclusion: The results of this study showed that the serum glutathione levels in postmenopausal women with high blood pressure were lower than normal menopausal women.http://nmj.umsha.ac.ir/article-1-1734-en.htmlglutathionehypertensionagepostmenopausalwomen |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Mohammad Zarei Parisa Mohammadi Pedram Beygvand Mohammad Amin Fereydouni Ghodratollah Roshanaei Mehrdad Hajilooei Saeed Mohammadi |
spellingShingle |
Mohammad Zarei Parisa Mohammadi Pedram Beygvand Mohammad Amin Fereydouni Ghodratollah Roshanaei Mehrdad Hajilooei Saeed Mohammadi The Comparison of serum glutathione level between Hypertensive and Normotensive Postmenopausal Women مراقبت پرستاری و مامایی ابن سینا glutathione hypertension age postmenopausal women |
author_facet |
Mohammad Zarei Parisa Mohammadi Pedram Beygvand Mohammad Amin Fereydouni Ghodratollah Roshanaei Mehrdad Hajilooei Saeed Mohammadi |
author_sort |
Mohammad Zarei |
title |
The Comparison of serum glutathione level between Hypertensive and Normotensive Postmenopausal Women |
title_short |
The Comparison of serum glutathione level between Hypertensive and Normotensive Postmenopausal Women |
title_full |
The Comparison of serum glutathione level between Hypertensive and Normotensive Postmenopausal Women |
title_fullStr |
The Comparison of serum glutathione level between Hypertensive and Normotensive Postmenopausal Women |
title_full_unstemmed |
The Comparison of serum glutathione level between Hypertensive and Normotensive Postmenopausal Women |
title_sort |
comparison of serum glutathione level between hypertensive and normotensive postmenopausal women |
publisher |
Hamadan University of Medical Sciences |
series |
مراقبت پرستاری و مامایی ابن سینا |
issn |
2676-5748 2676-5748 |
publishDate |
2017-11-01 |
description |
Background: Blood pressure increases in women after menopause. There is evidences that support the existence of the increased reactive oxygen species levels in hypertension. The glutathione has an important role in cell defense against oxidative stress.The aim of this study was comprising of serum glutathione level between hypertensive and normotensive postmenopausal women.
Methods: This research was a case-control study. The samples were selected among patients who had the inclusion criteria. Samples were 39 postmenopausal women with high blood pressure as case group and the control group was chosen among 40 postmenopausal women with normal blood pressure. After filling in the testimonial and the checklist, blood samples were taken for test subjects. Then the glutathione blood levels were measured using the kit and ELISA. Data were analyzed by t- test, F-test and the non-parametric Mann-Whitney test at a significant level of 5 percent.
Results: There was a significant difference between mean systolic and diastolic blood pressure (P= 0.029 & P= 0.047, respectively), serum glutathione level (P= 0.045), body mass index (P= 0.041), and weekly exercise less than 30 minutes (P= 0.049) in postmenopausal women with high blood pressure and normal blood pressure. However, no significant differences in age of onset of menopause, the number of children, employment status, and daily consumption of dairy products was observed between the two groups.
Conclusion: The results of this study showed that the serum glutathione levels in postmenopausal women with high blood pressure were lower than normal menopausal women. |
topic |
glutathione hypertension age postmenopausal women |
url |
http://nmj.umsha.ac.ir/article-1-1734-en.html |
work_keys_str_mv |
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