HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production

HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production

Human immunodeficiency virus (HIV) infection is associated with B-cell malignancies in patients though HIV-1 is not able to infect B-cells. The rate of B-cell lymphomas in HIV-infected individuals remains high even under the combined antiretroviral therapy (cART) that reconstitutes the immune functi...

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Bibliographic Details
Main Authors: Rawan El-Amine, Diego Germini, Vlada V. Zakharova, Tatyana Tsfasman, Eugene V. Sheval, Ruy A.N. Louzada, Corinne Dupuy, Chrystèle Bilhou-Nabera, Aline Hamade, Fadia Najjar, Eric Oksenhendler, Marс Lipinski, Boris V. Chernyak, Yegor S. Vassetzky
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Redox Biology
Subjects:
HIV-1
Tat
Oxidative stress
Mitochondria
DNA damage
B-cell lymphomas
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717306055

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