Prioritizing Parkinson’s disease genes using population-scale transcriptomic data
GWAS have identified over 41 susceptibility loci for Parkinson’s disease (PD). Here, the authors integrate PD GWAS summary statistics with transcriptome data from monocytes and DLFPC tissue in a TWAS approach and find 66 significant associations with PD risk highlighting lysosomal and innate immune...
Main Authors: | Yang I. Li, Garrett Wong, Jack Humphrey, Towfique Raj |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-03-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-08912-9 |
Similar Items
-
Transcriptomic Analyses for Identification and Prioritization of Genes Associated With Alzheimer’s Disease in Humans
by: Yuchen Shi, et al.
Published: (2020-02-01) -
Parkinson's disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons
by: Vahedi Shahrooz, et al.
Published: (2010-08-01) -
Prioritization of candidate genes for a South African family with Parkinson's disease using in-silico tools.
by: Boiketlo Sebate, et al.
Published: (2021-01-01) -
Chapter 15: disease gene prioritization.
by: Yana Bromberg
Published: (2013-04-01) -
Network Based Prioritization of Disease Genes
by: Erten, Mehmet Sinan
Published: (2009)