Deimination, Intermediate Filaments and Associated Proteins
Deimination (or citrullination) is a post-translational modification catalyzed by a calcium-dependent enzyme family of five peptidylarginine deiminases (PADs). Deimination is involved in physiological processes (cell differentiation, embryogenesis, innate and adaptive immunity, etc.) and in autoimmu...
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doaj-afa4f199a4b447b088c33ba05ade41012020-11-25T04:06:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-01218746874610.3390/ijms21228746Deimination, Intermediate Filaments and Associated ProteinsJulie Briot0Michel Simon1Marie-Claire Méchin2UDEAR, Institut National de la Santé Et de la Recherche Médicale, Université Toulouse III Paul Sabatier, Université Fédérale de Toulouse Midi-Pyrénées, U1056, 31059 Toulouse, FranceUDEAR, Institut National de la Santé Et de la Recherche Médicale, Université Toulouse III Paul Sabatier, Université Fédérale de Toulouse Midi-Pyrénées, U1056, 31059 Toulouse, FranceUDEAR, Institut National de la Santé Et de la Recherche Médicale, Université Toulouse III Paul Sabatier, Université Fédérale de Toulouse Midi-Pyrénées, U1056, 31059 Toulouse, FranceDeimination (or citrullination) is a post-translational modification catalyzed by a calcium-dependent enzyme family of five peptidylarginine deiminases (PADs). Deimination is involved in physiological processes (cell differentiation, embryogenesis, innate and adaptive immunity, etc.) and in autoimmune diseases (rheumatoid arthritis, multiple sclerosis and lupus), cancers and neurodegenerative diseases. Intermediate filaments (IF) and associated proteins (IFAP) are major substrates of PADs. Here, we focus on the effects of deimination on the polymerization and solubility properties of IF proteins and on the proteolysis and cross-linking of IFAP, to finally expose some features of interest and some limitations of citrullinomes.https://www.mdpi.com/1422-0067/21/22/8746citrullinationpost-translational modificationcytoskeletonkeratinfilaggrinpeptidylarginine deiminase |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julie Briot Michel Simon Marie-Claire Méchin |
spellingShingle |
Julie Briot Michel Simon Marie-Claire Méchin Deimination, Intermediate Filaments and Associated Proteins International Journal of Molecular Sciences citrullination post-translational modification cytoskeleton keratin filaggrin peptidylarginine deiminase |
author_facet |
Julie Briot Michel Simon Marie-Claire Méchin |
author_sort |
Julie Briot |
title |
Deimination, Intermediate Filaments and Associated Proteins |
title_short |
Deimination, Intermediate Filaments and Associated Proteins |
title_full |
Deimination, Intermediate Filaments and Associated Proteins |
title_fullStr |
Deimination, Intermediate Filaments and Associated Proteins |
title_full_unstemmed |
Deimination, Intermediate Filaments and Associated Proteins |
title_sort |
deimination, intermediate filaments and associated proteins |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-11-01 |
description |
Deimination (or citrullination) is a post-translational modification catalyzed by a calcium-dependent enzyme family of five peptidylarginine deiminases (PADs). Deimination is involved in physiological processes (cell differentiation, embryogenesis, innate and adaptive immunity, etc.) and in autoimmune diseases (rheumatoid arthritis, multiple sclerosis and lupus), cancers and neurodegenerative diseases. Intermediate filaments (IF) and associated proteins (IFAP) are major substrates of PADs. Here, we focus on the effects of deimination on the polymerization and solubility properties of IF proteins and on the proteolysis and cross-linking of IFAP, to finally expose some features of interest and some limitations of citrullinomes. |
topic |
citrullination post-translational modification cytoskeleton keratin filaggrin peptidylarginine deiminase |
url |
https://www.mdpi.com/1422-0067/21/22/8746 |
work_keys_str_mv |
AT juliebriot deiminationintermediatefilamentsandassociatedproteins AT michelsimon deiminationintermediatefilamentsandassociatedproteins AT marieclairemechin deiminationintermediatefilamentsandassociatedproteins |
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