Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.

Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.

The full length Rad51 promoter is highly active in cancer cells but not in normal cells. We therefore set out to assess whether we could confer this tumor-selectivity to an adenovirus vector.Expression of an adenovirally-vectored luciferase reporter gene from the Rad51 promoter was up to 50 fold hig...

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Bibliographic Details
Main Authors: Vincent Fong, Marika Osterbur, Cristina Capella, Yo-El Kim, Christopher Hine, Vera Gorbunova, Andrei Seluanov, Stephen Dewhurst
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3235156?pdf=render

Internet

http://europepmc.org/articles/PMC3235156?pdf=render

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