Sorting Nexin 27 Regulates Aβ Production through Modulating γ-Secretase Activity

Sorting Nexin 27 Regulates Aβ Production through Modulating γ-Secretase Activity

Patients with Down syndrome (DS) invariably develop Alzheimer’s disease (AD) pathology in their 40s. We have recently found that overexpression of a chromosome 21-encoded microRNA-155 results in decreased levels of the membrane trafficking component, SNX27, diminishing glutamate receptor recycling a...

Full description

Bibliographic Details
Main Authors:	Xin Wang, Timothy Huang, Yingjun Zhao, Qiuyang Zheng, Robert C. Thompson, Guojun Bu, Yun-wu Zhang, Wanjin Hong, Huaxi Xu
Format:	Article
Language:	English
Published:	Elsevier 2014-11-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124714008201

Similar Items

Characterization of two sorting nexins : sorting nexin-11 and sorting nexin-30
by: Cameron, Michel
Published: (2015)

The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases
by: Hongfeng Zhang, et al.
Published: (2018-03-01)

Sorting Nexins in Protein Homeostasis
by: Sara E. Hanley, et al.
Published: (2021-12-01)

Sorting nexin 17 regulates ApoER2 recycling and reelin signaling.
by: Pablo Sotelo, et al.
Published: (2014-01-01)

Examination and characterisation of mammalian sorting nexins
by: Carlton, Jeremy
Published: (2005)

Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways.
by: Ketaki Ganti, et al.
Published: (2016-09-01)

Sorting Nexin 27 Regulates the Lysosomal Degradation of Aquaporin-2 Protein in the Kidney Collecting Duct
by: Hyo-Jung Choi, et al.
Published: (2020-05-01)

Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels.
by: Bartosz Balana, et al.
Published: (2013-01-01)

Sorting nexin 9 in clathrin-mediated endocytosis
by: Lundmark, Richard
Published: (2004)

The γ-secretase complex: from structure to function
by: Xian eZhang, et al.
Published: (2014-12-01)

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
by: Zhao Yonghao, et al.
Published: (2012-06-01)

Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2
by: Kirsty J McMillan, et al.
Published: (2021-07-01)

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
by: Christian B. Lessard, et al.
Published: (2020-05-01)

An RGS-containing sorting nexin controls Drosophila lifespan.
by: Jae Myoung Suh, et al.
Published: (2008-01-01)

Structural studies on the PX domain of sorting nexin 1
by: Watson, Martin
Published: (2006)

γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43
by: Masayasu Okochi, et al.
Published: (2013-01-01)

ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
by: Bing Zhu, et al.
Published: (2017-11-01)

All ways lead to Rome: assembly of retromer on membranes with different sorting nexins
by: Xin Yong, et al.
Published: (2021-03-01)

The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation.
by: Jin Hu, et al.
Published: (2015-01-01)

Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis
by: Blessy Paul, et al.
Published: (2017-02-01)

Struktur-Funktionsanalyse der BAR Domäne von Sorting Nexin 33
by: Dislich, Bastian
Published: (2011)

Intracellular logistics : sorting nexins in retrograde transport of endogenous and exogenous cargo
by: Bujny, Miriam Verena
Published: (2007)

Deletion of sorting nexin 27 suppresses proliferation in highly aggressive breast cancer MDA-MB-231 cells in vitro and in vivo
by: Jilei Zhang, et al.
Published: (2019-06-01)

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).
by: Christian B Lessard, et al.
Published: (2015-01-01)

Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting
by: Marc Lenoir, et al.
Published: (2018-03-01)

The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis.
by: Nao Itai, et al.
Published: (2018-01-01)

Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope.
by: Jose M González-Granado, et al.
Published: (2014-01-01)

Investigating functions for sorting nexins in membrane trafficking within the endocytic network and autophagy
by: Attar, Naomi
Published: (2009)

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production
by: Huaqi Xiong, et al.
Published: (2008-03-01)

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780
by: Jeremy H. Toyn, et al.
Published: (2014-01-01)

α-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor.
by: Hiroshi Sakane, et al.
Published: (2014-01-01)

Development of a High-Throughput Assay for Screening of γ-Secretase Inhibitor with Endogenous Human, Mouse or Drosophila γ-Secretase
by: Lie-Feng Wang, et al.
Published: (2009-09-01)

The Role of Membrane Microdomains in γ-Secretase-Mediated Aβ Production
by: Arun Kapoor, et al.
Published: (2010)

A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.
by: April M Weissmiller, et al.
Published: (2015-01-01)

Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer’s Therapeutics
by: Varnavas D. Mouchlis, et al.
Published: (2020-01-01)

Intracellular trafficking of protease : Activated Receptor 2 (PAR2) by members of sorting nexins family
by: Kasakov, Velichko M.
Published: (2010)

Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation.
by: Maggie P C Ma, et al.
Published: (2013-01-01)

Studying the Expression of SNX2 (Sorting nexin-2) in Patients with RRMS Compared with Health Control
by: Fariba Bani Talebi Dehkordi, et al.
Published: (2017-06-01)

Sorting nexin-1 is a candidate tumor suppressor and potential prognostic marker in gastric cancer
by: Xiao-Yong Zhan, et al.
Published: (2018-05-01)

Analyse eines neuen Sorting Nexins und seiner Funktion in der ßAPP-Prozessierung
by: Schoebel, Susanne
Published: (2007)

Cannot write session to /tmp/vufind_sessions/sess_ch9rfi7q3sq09dv6798uk57d6f