A multiscale model via single-cell transcriptomics reveals robust patterning mechanisms during early mammalian embryo development.

A multiscale model via single-cell transcriptomics reveals robust patterning mechanisms during early mammalian embryo development.

During early mammalian embryo development, a small number of cells make robust fate decisions at particular spatial locations in a tight time window to form inner cell mass (ICM), and later epiblast (Epi) and primitive endoderm (PE). While recent single-cell transcriptomics data allows scrutinizatio...

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Bibliographic Details
Main Authors: Zixuan Cang, Yangyang Wang, Qixuan Wang, Ken W Y Cho, William Holmes, Qing Nie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-03-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1008571

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