Exploratory study data for determining the adverse effects of sinomenine plus gabapentin or ligustrazine hydrochloride and the pharmacokinetic insights of sinomenine in plasma and CNS tissue
This paper contains data that can be used in interpretation of the pharmacological effects of sinomenine combined with gabapentin or ligustrazine hydrochloride on chronic pain. The data can be divided into two parts. The first part is regarding if there were noticeable side effects accompanying drug...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-12-01
|
Series: | Data in Brief |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340919309886 |
id |
doaj-afbf4649ed8f41b0a021ef978ff7d4a6 |
---|---|
record_format |
Article |
spelling |
doaj-afbf4649ed8f41b0a021ef978ff7d4a62020-11-25T01:51:07ZengElsevierData in Brief2352-34092019-12-0127Exploratory study data for determining the adverse effects of sinomenine plus gabapentin or ligustrazine hydrochloride and the pharmacokinetic insights of sinomenine in plasma and CNS tissueTianle Gao0Tao Li1Wei Jiang2Weiming Fan3Jian-Dong Jiang4State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China; Corresponding author. State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica Chinese Academy of Medical Sciences, No.1 Xiannongtan, Xicheng District, 100050, Beijing, China.Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaZhejiang Zhenyuan Pharmaceutical Co., Ltd, 1015 West Shengli Road, Shaoxing, Zhejiang 312000, ChinaZhejiang Zhenyuan Pharmaceutical Co., Ltd, 1015 West Shengli Road, Shaoxing, Zhejiang 312000, ChinaState Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, ChinaThis paper contains data that can be used in interpretation of the pharmacological effects of sinomenine combined with gabapentin or ligustrazine hydrochloride on chronic pain. The data can be divided into two parts. The first part is regarding if there were noticeable side effects accompanying drug applications of sinomenine plus gabapentin or ligustrazine hydrochloride. These side effects include sedation and change of core body temperature as well as tissue edema and sustained itch. The data were acquired from the open field test in mice, and provided insights for the effects of drug combination therapy on locomotive activities, rearing behaviors and body temperature. The second part is regarding whether sinomenine could be accumulated in the central nervous system (CNS) tissue following repeated drug administration. The data were acquired using microdialysis, which illustrated the pharmacokinetic properties of sinomenine, by showing relative concentrations of sinomenine in blood and CNS tissue, following single or repeated drug application. Data presented here is related to and supportive of the research article by Gao et al., “Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain”[1], where interpretation of the research data presented here is available. Keywords: Sinomenine, Ligustrazine hydrochloride, Drug combination, Adverse effects, Pharmacokineticshttp://www.sciencedirect.com/science/article/pii/S2352340919309886 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tianle Gao Tao Li Wei Jiang Weiming Fan Jian-Dong Jiang |
spellingShingle |
Tianle Gao Tao Li Wei Jiang Weiming Fan Jian-Dong Jiang Exploratory study data for determining the adverse effects of sinomenine plus gabapentin or ligustrazine hydrochloride and the pharmacokinetic insights of sinomenine in plasma and CNS tissue Data in Brief |
author_facet |
Tianle Gao Tao Li Wei Jiang Weiming Fan Jian-Dong Jiang |
author_sort |
Tianle Gao |
title |
Exploratory study data for determining the adverse effects of sinomenine plus gabapentin or ligustrazine hydrochloride and the pharmacokinetic insights of sinomenine in plasma and CNS tissue |
title_short |
Exploratory study data for determining the adverse effects of sinomenine plus gabapentin or ligustrazine hydrochloride and the pharmacokinetic insights of sinomenine in plasma and CNS tissue |
title_full |
Exploratory study data for determining the adverse effects of sinomenine plus gabapentin or ligustrazine hydrochloride and the pharmacokinetic insights of sinomenine in plasma and CNS tissue |
title_fullStr |
Exploratory study data for determining the adverse effects of sinomenine plus gabapentin or ligustrazine hydrochloride and the pharmacokinetic insights of sinomenine in plasma and CNS tissue |
title_full_unstemmed |
Exploratory study data for determining the adverse effects of sinomenine plus gabapentin or ligustrazine hydrochloride and the pharmacokinetic insights of sinomenine in plasma and CNS tissue |
title_sort |
exploratory study data for determining the adverse effects of sinomenine plus gabapentin or ligustrazine hydrochloride and the pharmacokinetic insights of sinomenine in plasma and cns tissue |
publisher |
Elsevier |
series |
Data in Brief |
issn |
2352-3409 |
publishDate |
2019-12-01 |
description |
This paper contains data that can be used in interpretation of the pharmacological effects of sinomenine combined with gabapentin or ligustrazine hydrochloride on chronic pain. The data can be divided into two parts. The first part is regarding if there were noticeable side effects accompanying drug applications of sinomenine plus gabapentin or ligustrazine hydrochloride. These side effects include sedation and change of core body temperature as well as tissue edema and sustained itch. The data were acquired from the open field test in mice, and provided insights for the effects of drug combination therapy on locomotive activities, rearing behaviors and body temperature. The second part is regarding whether sinomenine could be accumulated in the central nervous system (CNS) tissue following repeated drug administration. The data were acquired using microdialysis, which illustrated the pharmacokinetic properties of sinomenine, by showing relative concentrations of sinomenine in blood and CNS tissue, following single or repeated drug application. Data presented here is related to and supportive of the research article by Gao et al., “Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain”[1], where interpretation of the research data presented here is available. Keywords: Sinomenine, Ligustrazine hydrochloride, Drug combination, Adverse effects, Pharmacokinetics |
url |
http://www.sciencedirect.com/science/article/pii/S2352340919309886 |
work_keys_str_mv |
AT tianlegao exploratorystudydatafordeterminingtheadverseeffectsofsinomenineplusgabapentinorligustrazinehydrochlorideandthepharmacokineticinsightsofsinomenineinplasmaandcnstissue AT taoli exploratorystudydatafordeterminingtheadverseeffectsofsinomenineplusgabapentinorligustrazinehydrochlorideandthepharmacokineticinsightsofsinomenineinplasmaandcnstissue AT weijiang exploratorystudydatafordeterminingtheadverseeffectsofsinomenineplusgabapentinorligustrazinehydrochlorideandthepharmacokineticinsightsofsinomenineinplasmaandcnstissue AT weimingfan exploratorystudydatafordeterminingtheadverseeffectsofsinomenineplusgabapentinorligustrazinehydrochlorideandthepharmacokineticinsightsofsinomenineinplasmaandcnstissue AT jiandongjiang exploratorystudydatafordeterminingtheadverseeffectsofsinomenineplusgabapentinorligustrazinehydrochlorideandthepharmacokineticinsightsofsinomenineinplasmaandcnstissue |
_version_ |
1724998438235406336 |