A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 Expression

A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 Expression

Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+ LBCL) is a very rare and aggressive subtype of diffuse large B-cell lymphoma characterized by ALK rearrangement. Immunophenotypically, the tumor cells are typically negative for common B-cell markers, T-cell markers, and CD30; however,...

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Main Authors: Jessica Corean, K. David Li
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2018/5320590
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spelling doaj-afc4b37468e64c5abb774185a0b4cb782020-11-25T02:49:14ZengHindawi LimitedCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/53205905320590A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 ExpressionJessica Corean0K. David Li1Department of Pathology, ARUP Laboratories, University of Utah, Salt Lake City, UT, USADepartment of Pathology, ARUP Laboratories, University of Utah, Salt Lake City, UT, USAAnaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+ LBCL) is a very rare and aggressive subtype of diffuse large B-cell lymphoma characterized by ALK rearrangement. Immunophenotypically, the tumor cells are typically negative for common B-cell markers, T-cell markers, and CD30; however, they express markers of terminally differentiated B cells/plasma cells such as CD38, CD138, and MUM-1/IRF4. The diagnosis of ALK+ LBCL can be challenging, and often a large panel of immunostains is required to exclude other hematopoietic and nonhematopoietic neoplasms. To date, approximately 130–140 cases have been reported, but here we report the first known case of ALK+ LBCL with unusual CD33 expression.http://dx.doi.org/10.1155/2018/5320590
collection DOAJ
language English
format Article
sources DOAJ
author Jessica Corean
K. David Li
spellingShingle Jessica Corean
K. David Li
A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 Expression
Case Reports in Hematology
author_facet Jessica Corean
K. David Li
author_sort Jessica Corean
title A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 Expression
title_short A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 Expression
title_full A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 Expression
title_fullStr A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 Expression
title_full_unstemmed A Rare Case of ALK-Positive Large B-Cell Lymphoma with CD33 Expression
title_sort rare case of alk-positive large b-cell lymphoma with cd33 expression
publisher Hindawi Limited
series Case Reports in Hematology
issn 2090-6560
2090-6579
publishDate 2018-01-01
description Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+ LBCL) is a very rare and aggressive subtype of diffuse large B-cell lymphoma characterized by ALK rearrangement. Immunophenotypically, the tumor cells are typically negative for common B-cell markers, T-cell markers, and CD30; however, they express markers of terminally differentiated B cells/plasma cells such as CD38, CD138, and MUM-1/IRF4. The diagnosis of ALK+ LBCL can be challenging, and often a large panel of immunostains is required to exclude other hematopoietic and nonhematopoietic neoplasms. To date, approximately 130–140 cases have been reported, but here we report the first known case of ALK+ LBCL with unusual CD33 expression.
url http://dx.doi.org/10.1155/2018/5320590
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