Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells

Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells

Chun-Xiu Yuan,1,2 Zhi-Wei Zhou,2,3 Yin-Xue Yang,4 Zhi-Xu He,3 Xueji Zhang,5 Dong Wang,6 Tianxing Yang,7 Ning-Ju Wang,1 Ruan Jin Zhao,8 Shu-Feng Zhou21Department of Oncology, General Hospital Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2Department of Pharmace...

Full description

Bibliographic Details
Main Authors:	Yuan CX, Zhou ZW, Yang YX, He ZX, Zhang X, Wang D, Yang T, Wang NJ, Zhao RJ, Zhou SF
Format:	Article
Language:	English
Published:	Dove Medical Press 2015-01-01
Series:	Drug Design, Development and Therapy
Online Access:	http://www.dovepress.com/inhibition-of-mitoticnbspaurora-kinase-a-by-alisertib-induces-apoptosi-peer-reviewed-article-DDDT

Similar Items

Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells
by: Yuan CX, et al.
Published: (2015-03-01)

Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells
by: Ding YH, et al.
Published: (2015-01-01)

The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells
by: Li JP, et al.
Published: (2015-02-01)

The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells
by: Li JP, et al.
Published: (2015-03-01)

Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells
by: Wang F, et al.
Published: (2015-01-01)

Inhibition of Aurora Kinase A by Alisertib Reduces Cell Proliferation and Induces Apoptosis and Autophagy in HuH-6 Human Hepatoblastoma Cells
by: Tan J, et al.
Published: (2020-05-01)

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway
by: Niu NK, et al.
Published: (2015-03-01)

Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity
by: Zhang Y, et al.
Published: (2015-04-01)

Scientific rationale supporting the clinical development strategy for the investigational Aurora A kinase inhibitor alisertib in cancer
by: Jeffrey A Ecsedy, et al.
Published: (2015-08-01)

Alisertib Induces Cell Cycle Arrest, Apoptosis, Autophagy and Suppresses EMT in HT29 and Caco-2 Cells
by: Bao-Jun Ren, et al.
Published: (2015-12-01)

Aurora A Functional Single Nucleotide Polymorphism (SNP) Correlates With Clinical Outcome in Patients With Advanced Solid Tumors Treated With Alisertib, an Investigational Aurora A Kinase Inhibitor
by: Huifeng Niu, et al.
Published: (2017-11-01)

An exploratory phase 2 study of investigational Aurora A kinase inhibitor alisertib (MLN8237) in acute myelogenous leukemia and myelodysplastic syndromes
by: Stuart L. Goldberg, et al.
Published: (2014-01-01)

Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle
by: Helfrid Hochegger, et al.
Published: (2013-01-01)

Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
by: Pan ST, et al.
Published: (2015-03-01)

Aurora kinase A increased CDK5 activity in mitotic phase
by: Yun-Chi Wang, et al.
Published: (2016)

Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells
by: Qui JX, et al.
Published: (2015-01-01)

Antitumor Effect of Lenvatinib Combined with Alisertib in Hepatocellular Carcinoma by Targeting the DNA Damage Pathway
by: Jianwen Hao, et al.
Published: (2021-01-01)

Modulation of oxidative phosphorylation augments antineoplastic activity of mitotic aurora kinase inhibition
by: Zijian Zhang, et al.
Published: (2021-09-01)

USP35 regulates mitotic progression by modulating the stability of Aurora B
by: Jinyoung Park, et al.
Published: (2018-02-01)

Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells
by: Shao Shujuan, et al.
Published: (2008-12-01)

Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells
by: Wang F, et al.
Published: (2015-01-01)

A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis
by: Han XD, et al.
Published: (2015-02-01)

Aurora A's functions during mitotic exit: the Guess Who game
by: David eReboutier, et al.
Published: (2015-12-01)

AIBp protein regulates Aurora A and Plk1 to control mitotic entry
by: TSUNG-CHIEH KAO, et al.
Published: (2013)

Proteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan) in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC) approach
by: Pan ST, et al.
Published: (2015-02-01)

Akt Inhibitor A-443654 Interferes with Mitotic Progression by Regulating Aurora A Kinase Expression
by: Xuesong Liu, et al.
Published: (2008-08-01)

Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk
by: Olga Afonso, et al.
Published: (2019-08-01)

Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly.
by: Selena G Burgess, et al.
Published: (2015-07-01)

The interplay of Aurora A/hBora complex with Pin1in the regulation of mitotic entry
by: Yu-ChengLee, et al.
Published: (2013)

The mechanism of Aurora-A-mediated TACC3 phosphorylation in regulating mitotic spindle stability
by: Chiou-Hong, Lin, et al.
Published: (2010)

The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A
by: Saili Moghe, et al.
Published: (2012-02-01)

Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry
by: N. Tavernier, et al.
Published: (2021-03-01)

They Might Cut It—Lysosomes and Autophagy in Mitotic Progression
by: Saara Hämälistö, et al.
Published: (2021-08-01)

Delivery of DNAzyme targeting aurora kinase A to inhibit the proliferation and migration of human prostate cancer
by: Xing Z, et al.
Published: (2015-09-01)

Hsa-microRNA-181a is a regulator of a number of cancer genes and a biomarker for endometrial carcinoma in patients: a bioinformatic and clinical study and the therapeutic implication
by: He S, et al.
Published: (2015-02-01)

Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway
by: He JL, et al.
Published: (2014-12-01)

Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties
by: Wang YY, et al.
Published: (2014-10-01)

Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability
by: Makoto Iimori, et al.
Published: (2016-03-01)

Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces
by: Asteriti Italia A, et al.
Published: (2011-10-01)

Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells
by: Pan ST, et al.
Published: (2015-10-01)