Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders

Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders

The potential clinical applications of the powerful in vitro-transcribed (IVT)-mRNAs, to restore defective protein functions, strongly depend on their successful intracellular delivery and transient translation through the development of safe and efficient delivery platforms. In this study, an innov...

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Bibliographic Details
Main Authors: Androulla N. Miliotou, Ioannis S. Pappas, George Spyroulias, Efthimia Vlachaki, Asterios S. Tsiftsoglou, Ioannis S. Vizirianakis, Lefkothea C. Papadopoulou
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
IVT-mRNA
protein transduction domain technology
PTD technology
delivery platform
protein therapy
SCO2
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121002377

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