A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke
Mutations in ryanodine receptor 1 (RyR1), a Ca2+ release channel in skeletal muscle, cause malignant hyperthermia (MH) and are involved in heat stroke. Here, the authors show that an oxolinic acid-derivative RyR1 inhibitor effectively prevents and treats MH and heat stroke in various MH mouse models...
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Nature Publishing Group
2021-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24644-1 |
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doaj-afd2999f767e49b494c83b5f5e5c1a4b2021-07-18T11:43:13ZengNature Publishing GroupNature Communications2041-17232021-07-0112111410.1038/s41467-021-24644-1A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat strokeToshiko Yamazawa0Takuya Kobayashi1Nagomi Kurebayashi2Masato Konishi3Satoru Noguchi4Takayoshi Inoue5Yukiko U. Inoue6Ichizo Nishino7Shuichi Mori8Hiroto Iinuma9Noriaki Manaka10Hiroyuki Kagechika11Arkady Uryash12Jose Adams13Jose R. Lopez14Xiaochen Liu15Christine Diggle16Paul D. Allen17Sho Kakizawa18Keigo Ikeda19Bangzhong Lin20Yui Ikemi21Kazuto Nunomura22Shinsaku Nakagawa23Takashi Sakurai24Takashi Murayama25Department of Molecular Physiology, The Jikei University School of MedicineDepartment of Pharmacology, Juntendo University School of MedicineDepartment of Pharmacology, Juntendo University School of MedicineDepartment of Pharmacology, Juntendo University School of MedicineDepartment of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and PsychiatryDepartment of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and PsychiatryDepartment of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and PsychiatryDepartment of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and PsychiatryInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental UniversityInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental UniversityInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental UniversityInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental UniversityDepartment of Neonatology, Mount Sinai Medical CenterDepartment of Neonatology, Mount Sinai Medical CenterDepartment of Research, Mount Sinai Medical CenterLeeds Institute of Biomedical & Clinical Sciences, School of Medicine, University of Leeds, St James’s University HospitalLeeds Institute of Biomedical & Clinical Sciences, School of Medicine, University of Leeds, St James’s University HospitalLeeds Institute of Biomedical & Clinical Sciences, School of Medicine, University of Leeds, St James’s University HospitalDepartment of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto UniversityCenter for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka UniversityCenter for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka UniversityCenter for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka UniversityCenter for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka UniversityCenter for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka UniversityDepartment of Pharmacology, Juntendo University School of MedicineDepartment of Pharmacology, Juntendo University School of MedicineMutations in ryanodine receptor 1 (RyR1), a Ca2+ release channel in skeletal muscle, cause malignant hyperthermia (MH) and are involved in heat stroke. Here, the authors show that an oxolinic acid-derivative RyR1 inhibitor effectively prevents and treats MH and heat stroke in various MH mouse models.https://doi.org/10.1038/s41467-021-24644-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Toshiko Yamazawa Takuya Kobayashi Nagomi Kurebayashi Masato Konishi Satoru Noguchi Takayoshi Inoue Yukiko U. Inoue Ichizo Nishino Shuichi Mori Hiroto Iinuma Noriaki Manaka Hiroyuki Kagechika Arkady Uryash Jose Adams Jose R. Lopez Xiaochen Liu Christine Diggle Paul D. Allen Sho Kakizawa Keigo Ikeda Bangzhong Lin Yui Ikemi Kazuto Nunomura Shinsaku Nakagawa Takashi Sakurai Takashi Murayama |
| spellingShingle |
Toshiko Yamazawa Takuya Kobayashi Nagomi Kurebayashi Masato Konishi Satoru Noguchi Takayoshi Inoue Yukiko U. Inoue Ichizo Nishino Shuichi Mori Hiroto Iinuma Noriaki Manaka Hiroyuki Kagechika Arkady Uryash Jose Adams Jose R. Lopez Xiaochen Liu Christine Diggle Paul D. Allen Sho Kakizawa Keigo Ikeda Bangzhong Lin Yui Ikemi Kazuto Nunomura Shinsaku Nakagawa Takashi Sakurai Takashi Murayama A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke Nature Communications |
| author_facet |
Toshiko Yamazawa Takuya Kobayashi Nagomi Kurebayashi Masato Konishi Satoru Noguchi Takayoshi Inoue Yukiko U. Inoue Ichizo Nishino Shuichi Mori Hiroto Iinuma Noriaki Manaka Hiroyuki Kagechika Arkady Uryash Jose Adams Jose R. Lopez Xiaochen Liu Christine Diggle Paul D. Allen Sho Kakizawa Keigo Ikeda Bangzhong Lin Yui Ikemi Kazuto Nunomura Shinsaku Nakagawa Takashi Sakurai Takashi Murayama |
| author_sort |
Toshiko Yamazawa |
| title |
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke |
| title_short |
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke |
| title_full |
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke |
| title_fullStr |
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke |
| title_full_unstemmed |
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke |
| title_sort |
novel ryr1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-07-01 |
| description |
Mutations in ryanodine receptor 1 (RyR1), a Ca2+ release channel in skeletal muscle, cause malignant hyperthermia (MH) and are involved in heat stroke. Here, the authors show that an oxolinic acid-derivative RyR1 inhibitor effectively prevents and treats MH and heat stroke in various MH mouse models. |
| url |
https://doi.org/10.1038/s41467-021-24644-1 |
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